Gonadotropin treatment of an azoospermic patient with a Y-chromosome microdeletion

Fertility and Sterility
Helmy SelmanImam El-Danasouri

Abstract

To report on the treatment with recombinant FSH of an azoospermic normogonadotropic patient with a Y-chromosome microdeletion. Case report. An assisted reproduction center. A 32-year-old patient with azoospermia. Histological testicular biopsy, Y-chromosome screening, FSH treatment, and intracytoplasmic sperm injection. Fertilization, embryo development, pregnancy, and delivery. After 6 months of treatment with gonadotropins, a small number of spermatozoa were found in the patient's ejaculate and used for IVF, resulting in a successful twin pregnancy and the delivery of two healthy girls. In this study, treatment with gonadotropins promoted the spermatogenesis process and led to the production of spermatozoa in a normogonadotropic azoospermic patient.

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Citations

Nov 30, 2013·The Urologic Clinics of North America·Boback M Berookhim, Peter N Schlegel
Mar 19, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Koji ShiraishiHideyasu Matsuyama
Jun 7, 2006·Fertility and Sterility·Helmy SelmanImam El-Danasouri
Sep 18, 2014·Reproductive Medicine and Biology·Koji Shiraishi

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