PMID: 7082402May 1, 1982Paper

Gonococcal arthritis-dermatitis syndrome. Study of serum and synovial fluid immune complex levels

Arthritis and Rheumatism
D H Manicourt, S Orloff

Abstract

Immune complexes from serum and synovial fluid were detected by the C1q binding assay in 12 patients with disseminated gonococcal infection. Since immune complexes were regularly higher in synovial fluids than in paired sera and were not detected by the monoclonal rheumatoid factor radioimmunoassay, we suggest that IgM may be present in these complexes and that this represents a primary immune response. In contrast, only 2 of 10 patients with local gonococcal infection were slightly positive both with the C1q assay and the monoclonal rheumatoid factor assay. In patients with disseminated gonococcal infection, immune complexes closely paralleled the disease activity and negatively correlated with complement levels. Synovial fluid immune complexes seem to occur in the early and aseptic phase of polyarthritis and to aid the entrance of circulating gonococcal organisms. From the results of our study, it seems that immunologic processes initiate and/or sustain inflammation in disseminated gonococcal infections that appear, at least in part, as a form of reactive arthritis.

References

Aug 1, 1975·The Journal of Infectious Diseases·J S Knapp, K K Holmes
Jan 1, 1979·Arthritis and Rheumatism·C L Ludivico, A R Myers
Jul 1, 1978·Annals of Internal Medicine·L C WalkerR C Williams
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Jul 1, 1975·The Journal of Experimental Medicine·A T SobelH J Müller-Eberhard
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Citations

Jan 1, 1979·Arthritis and Rheumatism·C L Ludivico, A R Myers
Jan 1, 1988·Rheumatology International·J R FraserA Riglar
Mar 21, 1985·The New England Journal of Medicine·D L Goldenberg, J I Reed
Dec 1, 1996·Genitourinary Medicine·J D Ross
Jan 1, 1989·Critical Reviews in Clinical Laboratory Sciences·T M Phillips
Nov 22, 2005·Infectious Disease Clinics of North America·Peter A Rice
Feb 1, 1984·Australian and New Zealand Journal of Medicine·J Edmonds
Oct 1, 1982·Arthritis and Rheumatism·P H Plotz
Nov 7, 2000·Revista Da Sociedade Brasileira De Medicina Tropical·G O PennaT M Braz

Related Concepts

Immune complex
Antigens
Arthritis, Viral
Hemolytic Complement
Dermatitis
Gonorrhea
Synovial Fluid

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