Abstract
Various factors affect the sensitivity of Neisseria gonorrhoeae to physiological levels of hydrophobic molecules. A total of 98 N. gonorrhoeae strains from rectal, cervical, and urethral cultures of homosexual men and heterosexual men and women were examined for their sensitivities to fecal lipids. Isolates were characterized according to cell envelope phenotype, auxotype, and protein I serogroup. Although cell envelope phenotype was an important factor in the resistance of this organism to fecal lipids (Mtr phenotype greater than wild type greater than Env phenotype), other factors were also of importance. AHU- strains (strains having a requirement for arginine, hypoxanthine, and uracil) uniformly exhibited a wild-type envelope phenotype but were as sensitive to fecal lipids as were Env strains. The protein I serogroup was not a factor in determining the sensitivity of wild-type envelope phenotype non-AHU- strains to fecal lipids. However, sexual preference and site of isolation were important factors. Wild-type envelope phenotype (non-AHU-) strains from homosexual men and heterosexual women were more resistant to fecal lipids than were similar isolates from heterosexual men. When these strains were compared by isolation site,...Continue Reading
References
Aug 1, 1977·Infection and Immunity·R D MillerS A Morse
Aug 1, 1979·Lipids·A F CacciapuotiS A Morse
Aug 1, 1978·The Journal of Infectious Diseases·J S KnappK K Homes
Aug 1, 1975·The Journal of Infectious Diseases·J S Knapp, K K Holmes
Jan 1, 1979·Advances in Microbial Physiology·H Nikaido, T Nakae
Apr 1, 1977·Infection and Immunity·R D Miller, S A Morse
Oct 1, 1977·Infection and Immunity·L W MayerS Falkow
Jan 1, 1978·Infection and Immunity·J Swanson
Jan 1, 1978·Infection and Immunity·J F James, J Swanson
Jan 15, 1979·The Biochemical Journal·R ColemanD Billington
Nov 1, 1975·Journal of Bacteriology·P F SparlingE Blackman
Nov 1, 1975·Journal of Bacteriology·F A SarubbiE Lewis
Nov 1, 1976·The Journal of Clinical Investigation·G K SchoolnikK K Holmes
Nov 1, 1974·Journal of Bacteriology·S A MorseJ Hines
Aug 1, 1973·The Journal of Infectious Diseases·B W Catlin
Apr 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·S A Morse, L Bartenstein
Dec 1, 1974·Journal of Bacteriology·F A SarubbiP F Sparling
Feb 2, 1973·Nature·E FreeseE Galliers
Jun 7, 1973·The New England Journal of Medicine·P J WiesnerK K Holmes
Jul 1, 1980·Journal of Bacteriology·D K Leith, S A Morse
Jan 1, 1980·Canadian Journal of Microbiology·S A Morse, L Bartenstein
Aug 1, 1980·Canadian Journal of Microbiology·A F Cacciapuoti, S A Morse
Feb 1, 1981·Journal of Bacteriology·P G Lysko, S A Morse
Feb 1, 1981·Molecular and Biochemical Parasitology·E L JarrollS A Morse
May 1, 1982·Infection and Immunity·A B KolodkinF E Young
Jun 1, 1982·Infection and Immunity·M R TamR C Nowinski
Aug 1, 1982·Infection and Immunity·S A MorseK K Holmes
Citations
Jun 1, 1995·Molecular Microbiology·C E LucasW M Shafer
Jun 1, 1987·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section B, Microbiology·M BäckmanE G Sandström
Jan 14, 2004·Drugs·Xian-Zhi Li, Hiroshi Nikaido
Dec 4, 2003·Journal of Bacteriology·E-H LeeW M Shafer
Feb 12, 2009·FEMS Microbiology Reviews·Jose Luis MartinezCarolina Alvarez-Ortega
Jun 27, 2006·Molecular Microbiology·Eun-Hee LeeWilliam M Shafer
Sep 23, 2003·Infection and Immunity·Ann E JerseWilliam M Shafer
Jun 1, 1991·Archives of Sexual Behavior·B Voeller
Feb 1, 1994·Molecular Microbiology·W Pan, B G Spratt
Mar 30, 2010·Applied and Environmental Microbiology·Stephanie SchielkeOliver Kurzai
Apr 10, 2010·Medical Microbiology and Immunology·Stephanie SchielkeOliver Kurzai
Sep 6, 2008·Canadian Journal of Microbiology·Kenneth Barth, Virginia L Clark
Aug 14, 1999·Molecular Microbiology·E H Lee, W M Shafer
Feb 19, 2015·Antimicrobial Agents and Chemotherapy·Sarah KiddHillard S Weinstock
Dec 15, 2017·PloS One·Paola StefanelliUNKNOWN Neisseria gonorrhoeae antimicrobials resistant Study Group
Aug 25, 2019·Microorganisms·Martina PasquaGianni Prosseda
Jul 1, 1997·Microbiology·Kayla E HagmanWilliam M Shafer
Apr 12, 2003·Journal of Clinical Microbiology·J J Wade, M A Graver
Jul 1, 1995·Journal of Bacteriology·K E Hagman, W M Shafer
Mar 1, 1996·Antimicrobial Agents and Chemotherapy·F J AbadiT H Pennington
Jul 11, 2021·The Journal of Antimicrobial Chemotherapy·Samantha G PalaceYonatan H Grad
Sep 4, 2021·Sexually Transmitted Diseases·Laura A S QuilterElizabeth A Torrone