Gonococcal sensitivity to fecal lipids can be mediated by an Mtr-independent mechanism.

Journal of Clinical Microbiology
L McFarlandS A Morse

Abstract

Various factors affect the sensitivity of Neisseria gonorrhoeae to physiological levels of hydrophobic molecules. A total of 98 N. gonorrhoeae strains from rectal, cervical, and urethral cultures of homosexual men and heterosexual men and women were examined for their sensitivities to fecal lipids. Isolates were characterized according to cell envelope phenotype, auxotype, and protein I serogroup. Although cell envelope phenotype was an important factor in the resistance of this organism to fecal lipids (Mtr phenotype greater than wild type greater than Env phenotype), other factors were also of importance. AHU- strains (strains having a requirement for arginine, hypoxanthine, and uracil) uniformly exhibited a wild-type envelope phenotype but were as sensitive to fecal lipids as were Env strains. The protein I serogroup was not a factor in determining the sensitivity of wild-type envelope phenotype non-AHU- strains to fecal lipids. However, sexual preference and site of isolation were important factors. Wild-type envelope phenotype (non-AHU-) strains from homosexual men and heterosexual women were more resistant to fecal lipids than were similar isolates from heterosexual men. When these strains were compared by isolation site,...Continue Reading

References

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Citations

Jun 1, 1987·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section B, Microbiology·M BäckmanE G Sandström
Jan 14, 2004·Drugs·Xian-Zhi Li, Hiroshi Nikaido
Feb 12, 2009·FEMS Microbiology Reviews·Jose Luis MartinezCarolina Alvarez-Ortega
Jun 1, 1991·Archives of Sexual Behavior·B Voeller
Feb 1, 1994·Molecular Microbiology·W Pan, B G Spratt
Apr 10, 2010·Medical Microbiology and Immunology·Stephanie SchielkeOliver Kurzai
Apr 12, 2003·Journal of Clinical Microbiology·J J Wade, M A Graver
Jul 1, 1995·Journal of Bacteriology·K E Hagman, W M Shafer
Mar 1, 1996·Antimicrobial Agents and Chemotherapy·F J AbadiT H Pennington
Jul 11, 2021·The Journal of Antimicrobial Chemotherapy·Samantha G PalaceYonatan H Grad

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