Good, Bad, or Ugly: the Biological Roles of Bone Marrow Fat

Current Osteoporosis Reports
Lakshman SinghGustavo Duque

Abstract

Bone marrow fat expresses mixed characteristics, which could correspond to white, brown, and beige types of fat. Marrow fat could act as either energy storing and adipokine secreting white fat or as a source of energy for hematopoiesis and bone metabolism, thus acting as brown fat. However, there is also a negative interaction between marrow fat and other elements of the bone marrow milieu, which is known as lipotoxicity. In this review, we will describe the good and bad roles of marrow fat in the bone, while focusing on the specific components of the negative effect of marrow fat on bone metabolism. Lipotoxicity in the bone is exerted by bone marrow fat through the secretion of adipokines and free fatty acids (FFA) (predominantly palmitate). High levels of FFA found in the bone marrow of aged and osteoporotic bone are associated with decreased osteoblastogenesis and bone formation, decreased hematopoiesis, and increased osteoclastogenesis. In addition, FFA such as palmitate and stearate induce apoptosis and dysfunctional autophagy in the osteoblasts, thus affecting their differentiation and function. Regulation of marrow fat could become a therapeutic target for osteoporosis. Inhibition of the synthesis of FFA by marrow fat co...Continue Reading

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Citations

Dec 21, 2018·Journal of the American Geriatrics Society·Jesse Zanker, Gustavo Duque
Nov 18, 2019·Current Osteoporosis Reports·Markus Herrmann
Apr 17, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Gustavo DuquePierrette Gaudreau
Jul 7, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Gustavo DuqueGilles J Guillemin
May 2, 2020·Calcified Tissue International·Ahmed Al SaediGustavo Duque
Mar 1, 2019·Nature Reviews. Endocrinology·Gabriel M PagnottiClinton T Rubin
Jun 27, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ahmed Al SaediGustavo Duque
Jan 17, 2020·Aging Medicine·Ben KirkGustavo Duque
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Jan 8, 2021·Frontiers in Cell and Developmental Biology·Jing HouChangjun Li
Aug 3, 2021·Physiological Reviews·Jesus Delgado-Calle, Teresita Bellido

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