PMID: 7545237Jun 1, 1995Paper

Good growth response to growth hormone treatment in the ring chromosome 15 syndrome

Journal of Medical Genetics
M NuutinenM Knip

Abstract

Ring chromosome 15 syndrome is a rare condition in which severe growth retardation is a major finding. We report a 4 year old boy with the karyotype 46,XY, r(15)(p11.2q26.2) whom we have treated with recombinant human growth hormone (GH) for two years. During the first year of treatment, the insulin-like growth factor I increased from subnormal 4.2 nmol/l to normal 13.8 nmol/l and the insulin-like growth factor binding protein 3 levels increased from 2.6 to 3.8 mg/l, whereas high binding protein 1 concentrations normalised from 52.0 to 16.7 micrograms/l. During the two years of treatment his relative height improved from -6.2 SD to -4.4 SD and the predicted adult height from 159.6 cm to 163.5 cm. Owing to the good growth response, we have decided to continue GH treatment.

References

Jul 1, 1992·Cancer Genetics and Cytogenetics·D CzarneckiC G Nash
Jun 1, 1990·Human Genetics·M KitataniT Maruoka
Jul 1, 1989·Journal of Medical Genetics·G de JongA E Retief
Jan 1, 1988·American Journal of Medical Genetics·M G ButlerJ A Phillips

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Citations

Nov 4, 2005·Human Genetics·Ian A GlassPhilip D Cotter
Oct 15, 2011·Pediatric Dermatology·María Del Carmen BoenteDaniela Montanari
Mar 1, 1996·American Journal of Medical Genetics·P K RoganM G Butler
Oct 30, 1998·Endocrine Reviews·S JainM E Geffner
Oct 25, 2017·Journal of Assisted Reproduction and Genetics·Kazuyo NishikawaTakashi Iwamoto
Nov 18, 2018·Journal of Medical Case Reports·César Paz-Y-MiñoPaola E Leone
Jan 30, 2007·Annals of Saudi Medicine·Abdelaziz Elamin, A Tuvemo
Jan 25, 2005·American Journal of Medical Genetics. Part a·David J AmorK H Andy Choo
Nov 9, 2021·Molecular Genetics & Genomic Medicine·Meiping ChenHuijuan Zhu

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