Good neighbours in the tumour stroma reduce oxidative stress.

Nature Cell Biology
Ralph J DeBerardinis

Abstract

Tumour cells undergo oncogene-regulated metabolic reprogramming that maximizes survival and growth. However, little is known about metabolic interactions between tumour cells and their non-malignant neighbours in the stroma. Bone-marrow-derived stromal cells are now shown to provide cysteine, an essential nutrient that enables leukaemia cells to resist oxidative stress.

References

Aug 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·J D BiggersR P Donahue
Jun 8, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Dean P JonesWard G Kirlin
Jul 1, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·James P Maloney
Jan 22, 2005·Current Opinion in Genetics & Development·Neil A Bhowmick, Harold L Moses
Mar 20, 2010·Nature Reviews. Cancer·Daniel A TennantEyal Gottlieb
Apr 29, 2010·Science Signaling·Christina H EngRobert T Abraham
Nov 30, 2010·Current Opinion in Genetics & Development·Marcelo J Berardi, Valeria R Fantin
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jul 14, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Norman KoglinLudger M Dinkelborg
Sep 6, 2011·Current Opinion in Oncology·Shuo Ma, Steven T Rosen
Oct 27, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Luc Pellerin, Pierre J Magistretti

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Citations

Apr 28, 2012·International Journal of Hematology·Vera MucajM Celeste Simon
Sep 8, 2012·Reproduction, Fertility, and Development·Míryan L V AlbertoMaria A Miglino
Sep 17, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ruihuan ChenHeidi S Phillips
Jul 8, 2015·Scientific Reports·Fabrizio CapuaniAndrea De Martino
Jun 13, 2018·Scientific Reports·Milad ShamsiAmir Sanati-Nezhad

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