Good overall behavioural adjustment in children and adolescents with classic congenital adrenal hyperplasia.

Endocrine
Valeria MessinaSvetlana Lajic

Abstract

Patients with classic congenital adrenal hyperplasia (CAH) are treated postnatally with life-long glucocorticoid (GC) replacement therapy. Although prolonged exposure to GCs may have a negative impact on behaviour, few studies have studied this issue. We therefore investigated behavioural outcomes in male and female children and adolescents with CAH. An observational study in which Swedish and Italian children and adolescents with CAH identified through neonatal screening for CAH (n = 57, age range 7-17 years) were compared with healthy population controls matched for age and sex (n = 72, age range 7-17 years). Thirteen (eight females) of the fifty-seven children and adolescents with CAH had been treated prenatally with dexamethasone (DEX). Standardised questionnaires for parents and self-report scales for children/adolescents were used to assess behavioural and emotional problems, social anxiety, temperament and scholastic competence. There were no statistically significant differences between CAH patients (not prenatally treated with DEX) and controls on most of the scales measuring adaptive functioning or behavioural problems. However, children with CAH were rated by their parents to have more social problems than controls (...Continue Reading

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Citations

Nov 17, 2020·Journal of the Endocrine Society·Lauren A HarasymiwKyriakie Sarafoglou
Mar 21, 2021·Current Opinion in Endocrinology, Diabetes, and Obesity·Anna NordenströmHenrik Falhammar

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