Good syndrome and other causes of cytomegalovirus retinitis in HIV-negative patients-case report and comprehensive review of the literature

Journal of Ophthalmic Inflammation and Infection
Kenneth M DownesEmmett T Cunningham

Abstract

We describe a 65-year-old Thai woman who developed cytomegalovirus retinitis (CMVR) in the setting of Good syndrome-a rare, acquired partial immune deficiency caused by thymoma. The patient subsequently developed vitritis with cystoid macular edema (CME) similar to immune recovery uveitis (IRU) despite control of the retinitis with antiviral agents. A comprehensive review of the literature through December, 2014, identified an additional 279 eyes of 208 patients with CMVR in the absence of human immunodeficiency virus (HIV) infection. Including our newly reported case, 9 of the 208 patients (4.3 %) had Good syndrome. Twenty-one of the 208 patients (10.1 %) had CMVR related to intraocular or periocular corticosteroid administration. The remaining 178 patients (85.6 %) acquired CMVR from other causes. Within the subset of patients who did not have Good syndrome or did not acquire CMVR followed by intraocular or periocular corticosteroid administration, there were many other factors contributing to a decline in immune function. The most common included age over 60 years (33.1 %), an underlying malignancy (28.7 %), a systemic autoimmune disorder requiring systemic immunosuppression (19.1 %), organ (15.2 %) or bone marrow (16.3 %) t...Continue Reading

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Citations

Oct 8, 2016·Ocular Immunology and Inflammation·Seung Woo LeeJeong Hun Bae
Apr 11, 2017·Lupus·F A de AndradeR Abramino Levy
Mar 30, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Alexander D PortMrinali P Gupta
Mar 3, 2018·Ocular Immunology and Inflammation·Emmett T CunninghamManfred Zierhut
Mar 20, 2019·Current Ophthalmology Reports·Alexander D PortMrinali P Gupta
Oct 4, 2018·Current Opinion in Ophthalmology·Ashlin Joye, John A Gonzales
Nov 14, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Kayo SuzukiSusumu Ishida
Jun 12, 2021·Frontiers in Immunology·Yiyun Shi, Chen Wang
Jun 12, 2021·Ocular Immunology and Inflammation·Federico ZicarelliAlessandro Invernizzi
Sep 12, 2019·Archivos de la Sociedad Española de Oftalmología·J L Sánchez-VicenteF López-Herrero

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Methods Mentioned

BETA
X-ray
biopsy
PCR

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