Good vibrations in enzyme-catalysed reactions.

Nature Chemistry
Sam Hay, Nigel S Scrutton

Abstract

Fast motions (femtosecond to picosecond) and their potential involvement during enzyme-catalysed reactions have ignited considerable interest in recent years. Their influence on reaction chemistry has been inferred indirectly from studies of the anomalous temperature dependence of kinetic isotope effects and computational simulations. But can such motion reduce the width and height of energy barriers along the reaction coordinate, and contribute to quantum mechanical and/or classical nuclear-transfer chemistry? Here we discuss contemporary ideas for enzymatic reactions invoking a role for fast 'promoting' (or 'compressive') motions that, in principle, can aid hydrogen-transfer reactions. Of key importance is the direct demonstration of a role for compressive motions and the ability to understand in atomic detail the structural origin of these fast motions, but so far this has not been achieved. Here we discuss both indirect experimental evidence that supports a role for compressive motion and the additional insight gained from computational simulations.

References

Jan 6, 1995·Science·A Radzicka, R Wolfenden
Feb 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Pratul K AgarwalSharon Hammes-Schiffer
Mar 28, 2002·Journal of the American Chemical Society·Stavros CaratzoulasSteven D Schwartz
Apr 11, 2002·Journal of the American Chemical Society·Michael J KnappJudith P Klinman
Sep 4, 2003·Journal of the American Chemical Society·Kenneth M DollRichard G Finke
Oct 30, 2003·Journal of the American Chemical Society·Giovanni Maglia, Rudolf K Allemann
May 6, 2004·Journal of the American Chemical Society·Elizabeth HatcherSharon Hammes-Schiffer
Jul 6, 2004·Archives of Biochemistry and Biophysics·Laura MasgrauNigel S Scrutton
Sep 16, 2006·Science·David D BoehrPeter E Wright
Oct 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Lin WangAmnon Kohen
Jan 4, 2007·Journal of the American Chemical Society·Elizabeth HatcherSharon Hammes-Schiffer
Jan 5, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sam HayNigel S Scrutton
Jun 19, 2007·The Journal of Physical Chemistry. B·Hanbin Liu, Arieh Warshel
Jul 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sara L Quaytman, Steven D Schwartz
Nov 21, 2007·Nature·Katherine A Henzler-WildmanDorothee Kern
Nov 21, 2007·Nature·Katherine A Henzler-WildmanDorothee Kern
Dec 14, 2007·Nature·Katherine Henzler-Wildman, Dorothee Kern
Jan 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·Matthew P MeyerJudith P Klinman
Feb 27, 2008·Biochemistry·Stephen J BenkovicSharon Hammes-Schiffer
May 13, 2008·Journal of the American Chemical Society·Jiayun PangMichael J Sutcliffe
Oct 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Suwipa Saen-OonSteven D Schwartz
Dec 17, 2008·The Journal of Biological Chemistry·Derren J HeyesNigel S Scrutton
Jan 16, 2009·Angewandte Chemie·Sam HayNigel S Scrutton
May 1, 2009·Chembiochem : a European Journal of Chemical Biology·Christopher R PudneyNigel S Scrutton
Jul 22, 2009·Nature Chemical Biology·Steven D Schwartz, Vern L Schramm
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Andrei V PisliakovArieh Warshel
Nov 7, 2009·Journal of the American Chemical Society·Christopher R PudneyNigel S Scrutton
Nov 21, 2009·Proceedings of the National Academy of Sciences of the United States of America·Dan T MajorJiali Gao
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·David D BoehrPeter E Wright
Apr 29, 2010·Proceedings of the National Academy of Sciences of the United States of America·Martin Karplus

❮ Previous
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Citations

Oct 5, 2012·Journal of the American Chemical Society·Zhen WangAmnon Kohen
Jan 10, 2014·Nature Communications·Edward J O'Reilly, Alexandra Olaya-Castro
May 24, 2012·Proceedings of the National Academy of Sciences of the United States of America·Mary Grace I GalinatoNicolai Lehnert
Nov 14, 2012·The Journal of Chemical Physics·Avinash KolliAlexandra Olaya-Castro
Jun 12, 2013·Annual Review of Biochemistry·Judith P Klinman, Amnon Kohen
Apr 25, 2013·Journal of the American Chemical Society·Zhen WangAmnon Kohen
Feb 18, 2016·Biochemistry·Vickery L ArcusLouis A Schipper
May 16, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniel RostonAmnon Kohen
Jul 15, 2015·FEBS Letters·Vickery L Arcus, Christopher R Pudney
Oct 16, 2015·FEBS Letters·Sansa DuttaMordechai Sheves
Jan 24, 2016·Biochemistry and Molecular Biology Education : a Bimonthly Publication of the International Union of Biochemistry and Molecular Biology·Sanchita Hati, Sudeep Bhattacharyya
Jun 17, 2015·Proceedings of the National Academy of Sciences of the United States of America·Jianyu ZhangJudith P Klinman
Jan 20, 2016·The Journal of Physical Chemistry. B·Sharmistha Karmakar, Ayan Datta
Dec 30, 2014·Accounts of Chemical Research·Amnon Kohen
May 27, 2014·Journal of Chemical Theory and Computation·Dvir DoronDan Thomas Major
Jan 24, 2014·Journal of the American Chemical Society·Priyanka SinghAmnon Kohen
Nov 5, 2014·The Journal of Physical Chemistry. B·Jean E Masterson, Steven D Schwartz
May 2, 2014·Journal of the American Chemical Society·Louis Y P LukRudolf K Allemann
Jun 24, 2014·Biochimica Et Biophysica Acta·Ana Sánchez-AzquetaMilagros Medina
Oct 10, 2015·The Journal of Chemical Physics·Kirill Zinovjev, Iñaki Tuñón
Oct 21, 2015·The Journal of Physical Chemistry. B·Antonio SarsaClaude Le Sech
Jun 19, 2014·Biophysical Journal·Stefania PerticaroliAlexei P Sokolov
May 8, 2013·The FEBS Journal·Hein J Wijma, Dick B Janssen
Apr 9, 2014·Current Opinion in Chemical Biology·Katarzyna SwiderekIñaki Tuñón
Oct 21, 2014·The Journal of Physical Chemistry. a·Andrey A GurinovIlya G Shenderovich
May 24, 2012·Biochemical Society Transactions·David R GlowackiAdrian J Mulholland
May 18, 2016·ACS Catalysis·Priyanka SinghAmnon Kohen
Apr 17, 2014·Current Opinion in Chemical Biology·Dan Thomas MajorMichal Weitman
Apr 20, 2014·Current Opinion in Chemical Biology·Kevin Francis, Amnon Kohen
Oct 13, 2014·Journal of Molecular Graphics & Modelling·Alexandra T P CarvalhoShina Caroline Lynn Kamerlin
Oct 15, 2013·Computational Biology and Chemistry·Vildan Enisoğlu Atalay, Safiye Sağ Erdem
Jul 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Ali HassanaliMichele Parrinello
Aug 28, 2014·The Journal of Physical Chemistry. B·Rafael García-MeseguerIñaki Tuñón

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