PMID: 9533760Apr 9, 1998Paper

Goralatide (AcSDKP), a negative growth regulator, protects the stem cell compartment during chemotherapy, enhancing the myelopoietic response to GM-CSF

International Journal of Cancer. Journal International Du Cancer
A E BogdenP Carde

Abstract

The aim of our study was to investigate the protection afforded to the bone marrow by Goralatide (AcSDKP), an inhibitor of hemopoietic stem cell proliferation, when administered alone or in combination with a growth factor (granulocyte/macrophage colony-stimulating factor [GM-CSF]) during iterative cycles of Ara-C (cytarabine) treatment. In control mice receiving the inhibitor alone without Ara-C, the number of granulocytes was reduced during treatment, and a surge in number of peripheral blood cells was observed after its completion. Peripheral hematological responses were monitored during 3 consecutive cycles of Ara-C chemotherapy and the resultant nadir and recoveries. Analysis of variance of the treatment effects pooled over the 3 cycles showed that a treatment regimen in which the inhibitor was administered during the myelotoxic periods of chemotherapy confirmed the existence of a surge after completion of administration of the inhibitor and showed a significant protective effect. When the cycles of chemotherapy plus Goralatide were followed by GM-CSF, the recovery from leukopenic nadirs was accelerated and the white blood cells and granulocyte levels were markedly increased over those observed in control mice and in mice ...Continue Reading

References

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Citations

Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·V DiveP Corvol
Jun 29, 2001·Journal of Peptide Science : an Official Publication of the European Peptide Society·J ThierryJ Wdzieczak-Bakala
Oct 22, 2014·Journal of Peptide Science : an Official Publication of the European Peptide Society·Zhiliang LiAlan R Katritzky

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