PMID: 11342251May 9, 2001Paper

Gossypol isomers bind specifically to blood plasma proteins and spermatozoa of rainbow trout fed diets containing cottonseed meal

Biochimica Et Biophysica Acta
K DabrowskiJ Ottobre

Abstract

We investigated the role of gossypol isomers binding to blood plasma, seminal plasma and spermatozoa to elucidate gossypol anti-fertility action in the teleost fish, rainbow trout (Oncorhynchus mykiss). Growth and hematological indicators of males were depressed when fish meal protein in diets was completely replaced with cottonseed meal. The cottonseed meal contained equal proportions of (-) (47.8+/-1.6%) and (+) gossypol isomers. Concentrations of spermatozoa were decreased with increasing proportions of gossypol in diets (from 0.22% to 0.95%); however, sperm motility and fertilizing ability were not affected. In contrast to mammals, steroid hormone concentrations were not suppressed in fish given diets with gradual increase of gossypol level. Gossypol concentrations were 100-fold higher in blood plasma than in seminal plasma, confirming a barrier in gossypol transfer between the general circulation and the testis. Spermatozoa accumulated predominantly (+) enantiomer (65-75%) with decreasing proportions as dietary gossypol concentrations increased. Spermatozoa bound most of the gossypol contained in the semen; however, this did not result in impairment of the sperm motility apparatus. Teleost fish sperm rely on ATP stores tha...Continue Reading

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Citations

Jul 24, 2008·Fish Physiology and Biochemistry·Erdinç SahinözZafer Doğu
Apr 25, 2013·Animal Reproduction Science·Tahere BagheriCatherin Bennetau-Pelissero
May 20, 2018·Fish Physiology and Biochemistry·Carine de Freitas SouzaBernardo Baldisserotto
Oct 30, 2020·International Journal of Nanomedicine·Dorota K FlakJanka Held-Feindt
Sep 3, 2010·Animal Reproduction Science·Najmeh SheikhzadehTayefi-Nasrabadi Hossein

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