Gout in pediatric renal transplant recipients.

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Johannes TrückPhilippe Goetschel

Abstract

Clinical gout has rarely been described after pediatric renal transplantation (RTx), although asymptomatic hyperuricemia is common in these patients. We describe three male pediatric patients who presented with gouty arthritis 7-8.5 years following RTx. Since receiving allopurinol, all patients had been free of gouty symptoms. To prevent severe bone marrow depletion, the dosage of azathioprine, an immunosupressant drug, was reduced by 50% to prevent interaction with allopurinol. Because atypical presentation of gout can occur, a high index of suspicion is needed to allow appropriate diagnosis of this disease in patients with skeletal pain after RTx.

References

Nov 1, 1994·Arthritis and Rheumatism·M R Cohen
Jan 26, 1994·JAMA : the Journal of the American Medical Association·D J McCarty
Apr 20, 2000·Journal of the American Society of Nephrology : JASN·David M Clive
Feb 14, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Fernando Perez-RuizJoan M Nolla
Dec 13, 2005·Transplantation·Kevin C AbbottSophie Caillard
Sep 2, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Giuseppina SpartàThomas J Neuhaus
Aug 21, 2009·Lancet·Pascal Richette, Thomas Bardin

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Citations

Jan 20, 2012·Current Rheumatology Reports·Lisa K Stamp, Peter T Chapman
Jun 14, 2019·Journal of Nutrition and Metabolism·Masaru Kubota
Jul 9, 2021·Curēus·Jatender KumarSidra Memon

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