Gout is not associated with a lower risk of Parkinson's disease: A systematic review and meta-analysis

Parkinsonism & Related Disorders
Patompong UngprasertCharat Thongprayoon

Abstract

Uratic acid is a potent anti-oxidant and hyperuricemia is well-linked to a lower risk of Parkinson's disease (PD), one of the most common neurodegenerative disorders. However, data on gout, the major complication of hyperuricemia, remain unclear. Two investigators independently searched published studies indexed in MEDLINE, and EMBASE from inception to April 2015 using the terms for gout combined with the terms for PD. The inclusion criteria were as follows: (1) cohort or case-control study evaluating the risk of PD among patients with gout (2) odds ratio, relative risk, hazard ratio or standardized incidence ratio were provided (3) subjects without gout and subjects with PD were used as controls in cohort and case-control study, respectively. RevMan 5.3 software was used to perform the statistical analysis. Point estimates and standard errors were extracted from individual studies and were combined by generic inverse variance method of DerSimonian and Laird. Statistical heterogeneity was assessed using the Cochran's Q test and I(2) statistics. Three case-control studies and two cohort studies were identified and included in the data analysis. The pooled risk ratio of PD in patients with gout was 0.93 (95% CI, 0.79 to 1.09). Th...Continue Reading

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Citations

Jan 26, 2016·Current Opinion in Rheumatology·Fernando Perez-RuizLoreto Carmona-Ortells
Jan 8, 2016·Parkinsonism & Related Disorders·Vanesa BellouJohn P A Ioannidis
Nov 14, 2019·International Journal of Epidemiology·Tamara V AzizovaNobuyuki Hamada
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