GPCRs in pancreatic adenocarcinoma: Contributors to tumor biology and novel therapeutic targets

British Journal of Pharmacology
Krishna SriramPaul A Insel

Abstract

Pancreatic cancer has the highest mortality rate (5-year survival ~9%) among major types of malignant tumors. Pancreatic adenocarcinoma (PAAD) is the most common (>80%) and most lethal type of pancreatic cancer. A strong need thus exists for new approaches to treat PAAD. G protein-coupled receptors (GPCRs), the largest family of cell-surface receptors and drug targets, account for ~35% of approved drugs. Recent studies have revealed roles for GPCRs in PAAD cells and cells in the tumor microenvironment. This review assesses current information regarding GPCRs in PAAD by first summarizing omics data for GPCRs expression in PAAD. The PAAD "GPCRome" includes GPCRs with approved agents, thereby offering potential for their repurposing/repositioning. In addition, we review the evidence for functional roles of specific GPCRs in PAAD. We also highlight gaps in understanding the contribution of GPCRs to PAAD biology and identify several GPCRs that may be novel therapeutic targets so as to help guide future work in search of GPCR-targeted drugs to treat PAAD tumors.

Citations

May 1, 1993·Annals of Surgery·J IshizukaJ C Thompson
Mar 18, 2000·Biochemical and Biophysical Research Communications·R A EhlersB M Evers
Apr 20, 2002·Clinical & Experimental Metastasis·Claudia RudroffEdmund A M Neugebauer
May 28, 2003·European Journal of Nuclear Medicine and Molecular Imaging·M de VisserM de Jong
Jun 25, 2003·Biochemical and Biophysical Research Communications·Guido EiblOscar J Hines
Aug 7, 2003·Journal of Cell Science·Martina StähleKlaudia Giehl
Oct 2, 2003·Nature·Sarah P ThayerMatthias Hebrok
Mar 14, 2007·The Journal of Biological Chemistry·Zhenyu JiXiaodong Cheng
Nov 21, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Rathai AnandanadesanHwyda A Arafat
Sep 17, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Xiaoming ShenJoseph Kim
Nov 13, 2009·Nucleic Acids Research·Misha KapusheskyAlvis Brazma
Feb 9, 2010·Biochemical and Biophysical Research Communications·Ulrike OlszewskiGerhard Hamilton
Mar 15, 2012·World Journal of Gastroenterology : WJG·Ying ChenMing-Hua Zhu
Apr 5, 2012·Journal of Translational Medicine·Eileen L HeinrichJoseph Kim
Oct 24, 2012·Pancreas·Chantale CharoVijaya Ramachandran
May 4, 2013·Nature Reviews. Cancer·Morgan O'HayreJ Silvio Gutkind

Related Concepts

Receptors, Cell Surface
Pharmacologic Substance
Adenocarcinoma Cell
G-Protein-Coupled Receptors
Agent
Pancreatic Adenocarcinoma
Neoplasms
Molecular Target
Pancreatic Carcinoma
Study

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