GPCRTree: online hierarchical classification of GPCR function.

BMC Research Notes
Matthew N DaviesDarren R Flower

Abstract

G protein-coupled receptors (GPCRs) play important physiological roles transducing extracellular signals into intracellular responses. Approximately 50% of all marketed drugs target a GPCR. There remains considerable interest in effectively predicting the function of a GPCR from its primary sequence. Using techniques drawn from data mining and proteochemometrics, an alignment-free approach to GPCR classification has been devised. It uses a simple representation of a protein's physical properties. GPCRTree, a publicly-available internet server, implements an algorithm that classifies GPCRs at the class, sub-family and sub-subfamily level. A selective top-down classifier was developed which assigns sequences within a GPCR hierarchy. Compared to other publicly available GPCR prediction servers, GPCRTree is considerably more accurate at every level of classification. The server has been available online since March 2008 at URL: http://igrid-ext.cryst.bbk.ac.uk/gpcrtree/.

References

Nov 5, 1999·Biochimica Et Biophysica Acta·D R Flower
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Jul 20, 2007·Proteomics·Matthew N DaviesDarren R Flower
Oct 25, 2007·Bioinformatics·Matthew N DaviesDarren R Flower

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Citations

Jun 23, 2009·BMC Genomics·Guoqing LuEtsuko N Moriyama
Jul 6, 2013·Progress in Biophysics and Molecular Biology·Subha Kalyaanamoorthy, Yi-Ping Phoebe Chen
Sep 30, 2010·IEEE/ACM Transactions on Computational Biology and Bioinformatics·Murat Can CobanogluUgur Sezerman
Nov 16, 2017·Scientific Reports·Geng-Ming HuChi-Ming Chen
Aug 1, 2019·Annals of the New York Academy of Sciences·Nicole ScholzTorsten Schöneberg
Mar 23, 2019·International Journal of Molecular Sciences·Antonella Di PizioDietmar Krautwurst

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Software Mentioned

PRED
Waikato Environment for Knowledge Analysis
GPCRPred
WEKA
GPCRsclass
GPCRtree
GPCR
Proteochemometrics

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