GPER was Associated with Hypertension in Post-Menopausal Women

Open Medicine
Shichao LiuLiguo Jian

Abstract

To explore the relationship between G protein-coupled estrogen receptor (GPER) and hypertension in post-menopausal women. Using a matched case-control design, clinical and laboratory data were collected. Conditional logistic regression with stratified analysis was conducted to identify the association between GPER and hypertension. The GPER level was significantly lower in the case group than in the control group (126.3 ± 21.6 vs. 133.6 ± 27.3, P=0.000). The GPER levels of the hypertension cases with and those without menopause were significant (120.5 ± 11.8 and 127.2 ± 12.1, P=0.000). No significant difference in the GPER level between the controls with and those without menopause was observed (P=0.241). Logistic regression revealed that the GPER quartile was related to hypertension (odds ratio [OR]: 0.63, 95% confidence interval [CI]: 0.13-0.93, P=0.018) after adjusting for potential confounding factors. Stratified analysis revealed that the GPER quartile was not associated with hypertension in premenopausal women, and the fourth GPER quartile showed a predictive association with hypertension (OR: 0.43, 95% CI: 0.29-0.90) in menopausal women. GPER level is associated with hypertension and is a protective factor for hypertensi...Continue Reading

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Citations

Sep 8, 2020·American Journal of Physiology. Renal Physiology·Eman Y Gohar
May 8, 2020·International Journal of Molecular Sciences·Coralie FontaineBarbara Garmy-Susini
Feb 13, 2021·Cancers·Florent MorfoisseBarbara Garmy-Susini

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

SPSS

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