GPER/Hippo-YAP signal is involved in Bisphenol S induced migration of triple negative breast cancer (TNBC) cells.

Journal of Hazardous Materials
Qianqian DengHongsheng Wang

Abstract

Nowadays, risk factors of triple-negative breast cancer (TNBC) metastasis are not well identified. Our present study reveals that an industrial chemical, bisphenol S (BPS), can promote the migration, but not the proliferation, of TNBC cells in vitro. BPS activates YAP, a key effector of Hippo pathway, by inhibiting its phosphorylation, which promotes YAP nuclear accumulation and up-regulates its downstream genes such as CTGF and ANKRD1. Inhibition of YAP blocks the BPS-triggered cell migration and up-regulation of fibronectin (FN) and vimentin (Vim). BPS rapidly decreases the phosphorylation levels of LATS1 (Ser909) in TNBC cells, which regulates the activation and functions of YAP. Silencing LATS1/2 by siRNA increases BPS-induced dephosphorylation of YAP and extended the half-life of YAP protein. Inhibition of G protein-coupled estrogen receptor 1 (GPER) and its downstream PLCβ/PKC signals attenuate the effects of BPS-induced YAP dephosphorylation and CTGF up-regulation. Targeted inhibition of GPER/YAP inhibits BPS-induced migration of TNBC cells. Collectively, we reveal that GPER/Hippo-YAP signal is involved in BPS-induced migration of TNBC cells.

Citations

Aug 18, 2020·Environmental Science and Pollution Research International·Agnieszka Grelska, Magdalena Noszczyńska
Aug 25, 2018·Journal of Molecular Neuroscience : MN·Yuefeng JiaXuecheng Yang
Aug 23, 2019·World Journal of Gastroenterology : WJG·Damian JacenikEric R Prossnitz
Nov 7, 2019·Scientific Reports·Ella Atlas, Valeria Dimitrova
Nov 15, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wenxia ZhaoRongguang Shao
Dec 18, 2020·Frontiers in Nutrition·Barbara J StillwaterOrnella I Selmin

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