GPi vs STN deep brain stimulation for Parkinson disease: Three-year follow-up

Neurology
Vincent J J OdekerkenNSTAPS study group

Abstract

To compare motor symptoms, cognition, mood, and behavior 3 years after deep brain stimulation (DBS) of the globus pallidus pars interna (GPi) and subthalamic nucleus (STN) in advanced Parkinson disease (PD). Patients with PD eligible for DBS were randomized to bilateral GPi DBS and bilateral STN DBS (1:1). The primary outcome measures were (1) improvement in motor symptoms in off-drug phase measured with the Unified Parkinson Disease Rating Scale (UPDRS) and (2) a composite score for cognitive, mood, and behavioral effects, and inability to complete follow-up at 36 months after surgery. Of the 128 patients enrolled, 90 were able to complete the 3-year follow-up. We found significantly more improvement of motor symptoms after STN DBS (median [interquartile range (IQR)] at 3 years, GPi 33 [23-41], STN 28 [20-36], p = 0.04). No between-group differences were observed on the composite score (GPi 83%, STN 86%). Secondary outcomes showed larger improvement in off-drug functioning in the AMC Linear Disability Scale score after STN DBS (mean ± SD, GPi 65.2 ± 20.1, STN 72.6 ± 18.0, p = 0.05). Medication was reduced more after STN DBS (median levodopa equivalent dose [IQR] at 3 years, GPi 1,060 [657-1,860], STN 605 [411-875], p < 0.001)....Continue Reading

References

May 1, 1967·Neurology·M M Hoehn, M D Yahr
Jul 1, 1996·Journal of Neurology, Neurosurgery, and Psychiatry·A G de BoerJ C de Haes
May 13, 1999·The New England Journal of Medicine·B P BejjaniY Agid
May 29, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·P Hagell, H Widner
Aug 17, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·A SchragN Quinn
Sep 29, 2001·The New England Journal of Medicine·UNKNOWN Deep-Brain Stimulation for Parkinson's Disease Study GroupA E Lang
Nov 13, 2002·Neurology·J KulisevskyP Parés
Nov 20, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·K R ChaudhuriC Trenkwalder
Jun 3, 2004·Annals of Neurology·Jens VolkmannHans-Joachim Freund
Apr 13, 2005·Archives of Neurology·Valerie C AndersonJohn P Hammerstad
Jun 25, 2005·Brain : a Journal of Neurology·M C Rodriguez-OrozN Van Blercom
Sep 1, 2006·The New England Journal of Medicine·Günther DeuschlUNKNOWN German Parkinson Study Group, Neurostimulation Section
Aug 28, 2007·Parkinsonism & Related Disorders·Francisco Javier Carod-ArtalPablo Martínez-Martin
Jan 8, 2009·JAMA : the Journal of the American Medical Association·Frances M WeaverUNKNOWN CSP 468 Study Group
Jun 4, 2010·The New England Journal of Medicine·Kenneth A FollettUNKNOWN CSP 468 Study Group
Feb 8, 2011·Nature Reviews. Neurology·Marie Vidailhet
Jun 23, 2012·Neurology·Frances M WeaverUNKNOWN CSP 468 Study Group
Nov 19, 2013·Journal of Neurosurgery·Albert J Fenoy, Richard K Simpson
Apr 30, 2014·Movement Disorders Clinical Practice·Nolan R WilliamsMichael S Okun

❮ Previous
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Citations

Oct 19, 2016·Parkinsonism & Related Disorders·Julien BonenfantMarc Vérin
Jan 26, 2017·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Sven KoenenStephan Barcikowski
Jan 31, 2017·Acta Neurologica Scandinavica·E Dietrichs, P Odin
May 1, 2016·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Philip M LewisPaul B Fitzgerald
Jan 24, 2018·Parkinson's Disease·Raja MehannaAparna Ashutosh Wagle Shukla
Mar 6, 2018·Neurology India·Syam KrishnanAsha Kishore
Mar 6, 2018·Neurology India·Paresh K Doshi
Mar 24, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Susan H FoxUNKNOWN Movement Disorder Society Evidence-Based Medicine Committee
Jul 5, 2018·Arquivos de neuro-psiquiatria·Pedro BrandãoRenato P Munhoz
Aug 27, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Marc DeffainsHagai Bergman
Feb 24, 2019·Journal of Neurosurgery·Darrin J LeeAndres M Lozano
Apr 20, 2019·Journal of Neurosurgery·Zoe E TetonAhmed M Raslan
Aug 5, 2017·Annual Review of Neuroscience·Andres M LozanoSuneil K Kalia
Aug 17, 2019·Expert Review of Neurotherapeutics·Martijn L T M MüllerNicolaas I Bohnen
Oct 4, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Paul KrackGünther Deuschl
Mar 3, 2019·Neurology·W Steven Metzer, Filipe B Rodrigues
Sep 25, 2019·Research : a Science Partner Journal·Hui ZhouHairong Zheng
Sep 26, 2020·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Jiri BurilMarek Balaz
Oct 16, 2016·Current Treatment Options in Neurology·Leo Verhagen MetmanKonstantin Slavin
Jan 27, 2019·Nature Reviews. Neurology·Andres M LozanoJoachim K Krauss
Feb 20, 2019·Nature Reviews. Neurology·Patricia Limousin, Tom Foltynie
Jan 27, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Paul KrackJose A Obeso
Mar 24, 2017·Nature Reviews. Disease Primers·Werner PoeweAnthony E Lang
Jul 2, 2019·Frontiers in Neurology·Ettore A Accolla, Claudio Pollo
Jul 28, 2019·Journal of Neurosurgery·Naomi PrentAnne-Fleur van Rootselaar
Apr 8, 2020·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Wenying XuDianyou Li
Jul 14, 2020·NPJ Parkinson's Disease·Stephanie CerneraAysegul Gunduz

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