GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries.

Cell Metabolism
Brandon S J DaviesLoren G Fong

Abstract

The lipolytic processing of triglyceride-rich lipoproteins by lipoprotein lipase (LPL) is the central event in plasma lipid metabolism, providing lipids for storage in adipose tissue and fuel for vital organs such as the heart. LPL is synthesized and secreted by myocytes and adipocytes, but then finds its way into the lumen of capillaries, where it hydrolyzes lipoprotein triglycerides. The mechanism by which LPL reaches the lumen of capillaries has remained an unresolved problem of plasma lipid metabolism. Here, we show that GPIHBP1 is responsible for the transport of LPL into capillaries. In Gpihbp1-deficient mice, LPL is mislocalized to the interstitial spaces surrounding myocytes and adipocytes. Also, we show that GPIHBP1 is located at the basolateral surface of capillary endothelial cells and actively transports LPL across endothelial cells. Our experiments define the function of GPIHBP1 in triglyceride metabolism and provide a mechanism for the transport of LPL into capillaries.

References

Jan 1, 1985·Annual Review of Cell Biology·J L GoldsteinW J Schneider
Aug 1, 1993·Current Opinion in Cell Biology·R G Anderson
Aug 29, 1995·Proceedings of the National Academy of Sciences of the United States of America·P K FrykmanJ Herz
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·P H WeinstockJ L Breslow
Nov 5, 1997·Biochimica Et Biophysica Acta·O NosjeanB Roux
Mar 15, 2005·Journal of Cell Science·Lawrence Rajendran, Kai Simons
Aug 21, 2008·The Journal of Biological Chemistry·Peter GinAnne P Beigneux
Oct 11, 2008·The Journal of Biological Chemistry·Michael M WeinsteinStephen G Young
Mar 26, 2009·American Journal of Physiology. Endocrinology and Metabolism·Hong Wang, Robert H Eckel
Sep 4, 2009·The Journal of Biological Chemistry·Anne P BeigneuxStephen G Young
Dec 23, 2009·Journal of Lipid Research·Gunilla OlivecronaOlle Hernell
Feb 4, 2010·Circulation. Cardiovascular Genetics·Remco FranssenAnne P Beigneux

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Citations

Jan 11, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Alexander BarteltJoerg Heeren
Oct 20, 2011·Journal of Inherited Metabolic Disease·Jonathan J RiosHelen H Hobbs
Feb 5, 2013·Reviews in Endocrine & Metabolic Disorders·Rosario Scalia
Apr 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Constance V VossStephen G Young
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Hea-Jin JungLoren G Fong
Nov 30, 2011·Current Opinion in Lipidology·Brandon S J DaviesStephen G Young
Mar 28, 2012·Current Opinion in Lipidology·Alexander Bartelt, Joerg Heeren
Mar 12, 2013·Genes & Development·Stephen G Young, Rudolf Zechner
May 25, 2012·American Journal of Physiology. Renal Physiology·Shenyang LiDidier Portilla
Mar 5, 2013·Physiology·Carolina HagbergUlf Eriksson
Oct 19, 2011·International Journal of Vascular Medicine·Gerald H Tomkin, Daphne Owens
Sep 4, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Michael M WeinsteinStephen G Young
Oct 23, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Peter GinStephen G Young
May 17, 2013·The Journal of Clinical Investigation·Jon C GonzalesJeffrey D Esko
Sep 26, 2012·Journal of Lipid Research·Brandon S J DaviesStephen G Young
Aug 17, 2011·Journal of Lipid Research·Stephen G YoungAnne P Beigneux
Apr 16, 2013·Nutrients·Boudewijn KlopManuel Castro Cabezas
Jul 9, 2013·Journal of Atherosclerosis and Thrombosis·Hiroyasu YamamotoShijin Kihara
Dec 10, 2013·Trends in Endocrinology and Metabolism : TEM·Devi MehrotraHyung J Chun
Jan 9, 2014·Trends in Endocrinology and Metabolism : TEM·Wieneke Dijk, Sander Kersten
Jan 7, 2014·Trends in Endocrinology and Metabolism : TEM·Kristy L Townsend, Yu-Hua Tseng
Jan 1, 2014·Journal of Animal Science and Biotechnology·Jie YangLi Jiang
Mar 12, 2016·The Journal of Investigative Dermatology·Christopher M AllanAnne P Beigneux
May 6, 2014·Journal of Clinical Lipidology·Neema ChokshiAbhimanyu Garg
Sep 25, 2012·Heart Failure Clinics·Bernard P C Kok, David N Brindley
Jun 27, 2012·Biochimica Et Biophysica Acta·Stefan K NilssonGunilla Olivecrona
Dec 20, 2011·Biochimica Et Biophysica Acta·H C HassingG M Dallinga-Thie
Oct 26, 2011·Biochimica Et Biophysica Acta·Min Suk KimBrian Rodrigues
Oct 29, 2011·Biochimica Et Biophysica Acta·Christopher T Johansen, Robert A Hegele
Nov 9, 2011·Biochimica Et Biophysica Acta·Miklós Péterfy
Dec 16, 2010·Néphrologie & thérapeutique·Max Lafontan
Jul 8, 2016·Adipocyte·María Calderon-DominguezLaura Herrero
Mar 8, 2016·Molecular and Cellular Endocrinology·Zhenzhen LiuQiong Duan
Feb 7, 2014·The Journal of Investigative Dermatology·Oludotun AdeyoStephen G Young

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