Gprk2 controls cAMP levels in Drosophila development

Developmental Biology
B J Lannutti, L E Schneider

Abstract

G protein-coupled receptors mediate their biological responses through the generation of second messengers, such as cAMP. The down-regulation of their activity (desensitization) is carried out, in part, by the family of G protein-coupled receptor kinases, which phosphorylate activated receptors. The Gprk2 gene in Drosophila melanogaster is a putative member of this family. The GPRK2 protein is expressed most abundantly in the ovaries and in the mushroom bodies, the brain region that is implicated in learning and memory in insects. Many of the genes that are involved in learning in Drosophila are members of a cAMP-signaling pathway and are also expressed in the mushroom bodies. These observations suggest that the Gprk2 gene may be involved in a cAMP-mediated pathway. To investigate this possibility, we tested for a genetic interaction between Gprk2 and dunce (which encodes cAMP-specific phosphodiesterase). A mutant allele of Gprk2, called gprk2(6936), has decreased fertility as a result of reduced levels of egg laying and hatching, and developing egg chambers display defects in the formation of anterior structures. Similarly, many alleles of dunce are sterile, with an ovary phenotype that resembles gprk2(6936). Introduction of a...Continue Reading

References

May 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·Y DudaiS Benzer
Jul 1, 1991·Trends in Genetics : TIG·R L Davis, B Dauwalder
Aug 1, 1991·Journal of Bioenergetics and Biomembranes·R LatorreP Labarca
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J A CassillC S Zuker
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M B Feany
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S YarfitzJ B Hurley
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M S Livingstone
Sep 1, 1984·Behavior Genetics·T Tully
Jan 1, 1995·Cell Motility and the Cytoskeleton·M G Riparbelli, G Callaini
Feb 1, 1995·Mechanisms of Development·M E Lane, D Kalderon
Oct 28, 1994·Science·L Cooley, W E Theurkauf
Aug 13, 1993·Cell·R J Lefkowitz
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·H A RockmanW J Koch
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·M JaberB Giros
Jan 31, 1998·Science·K McCall, H Steller
Feb 14, 1998·The Journal of Biological Chemistry·H E Hamm
Jan 1, 1997·Annual Review of Cell and Developmental Biology·D N Robinson, L Cooley
Aug 1, 1998·The Journal of Biological Chemistry·C V CarmanJ L Benovic
Aug 1, 1998·The Journal of Biological Chemistry·J L FreemanJ A Pitcher
Oct 6, 1998·Annual Review of Biochemistry·J A PitcherR J Lefkowitz
Dec 10, 1998·Nucleic Acids Research·UNKNOWN FlyBase Consortium
Apr 13, 1999·The American Journal of Physiology·J K WalkerJ T Fisher
Mar 25, 2000·Science·M D AdamsJ C Venter
Aug 1, 1988·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Hugo Jozef Bellen, John Andrew Kiger
Jun 1, 1992·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Susan Whitehouse-HillsJohn Andrew Kiger

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Citations

Jan 22, 2003·Biochemical and Biophysical Research Communications·Shongshan Fan, Lynne E Schneider
Oct 12, 2012·Molecular Biology of the Cell·Christopher M GroenTina L Tootle
Mar 26, 2011·PLoS Genetics·Cristina MolnarJose F de Celis
May 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Cristina MolnarJose F de Celis
Mar 9, 2010·Trends in Cell Biology·Katie L Ayers, Pascal P Thérond
Oct 24, 2009·Developmental Biology·Shuofei ChengDavid R Hipfner
Nov 19, 2003·Developmental Biology·Hyun-Gwan LeeKyung-An Han
Nov 11, 2006·Biochimica Et Biophysica Acta·Ana Ruiz-GómezJose F de Celis
Jun 24, 2020·Alcoholism, Clinical and Experimental Research·Yuan Yuan KangGregg Roman

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