Gαq controls rheumatoid arthritis via regulation of Th17 differentiation

Immunology and Cell Biology
Yuan LiuGuixiu Shi

Abstract

Gαq, the α-subunit of Gq protein, is ubiquitously expressed in mammalian cells. It initially attracted attention for its physiological significance in cardiovascular system. In recent years, studies have also indicated the important roles of Gαq in regulating immunity, supplying us a new insight into the mechanism of immune regulation. T helper type 17 (Th17) cells are potent inducers of tissue inflammation. Many studies have shown that Th17 cells are major effector cells in the pathogenesis of many experimental autoimmune diseases and human inflammatory conditions such as rheumatoid arthritis (RA). One of our previous studies has shown that Gαq negatively controls the disease activity of RA. However, how Gαq controls the pathogenesis of autoimmune disease is not clear. Whether this effect is via the regulation of Th17 differentiation is still not known. We aimed to find out the role of Gαq in control of Th17 differentiation. We investigated the relationship between Gαq and Th17 in RA patients. We then investigated the mechanism of how Gαq regulated Th17 differentiation by using Gnaq(-/-) mice. We observed that the expression of Gαq was negatively associated with interleukin-17A expression in RA patients, indicating that Gαq ne...Continue Reading

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Citations

Feb 18, 2016·Journal of Immunology Research·Lu Zhang, Guixiu Shi
Sep 13, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lisbeth A BouleB Paige Lawrence
Jul 22, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ning WangBing Du
Mar 16, 2017·Frontiers in Immunology·Sushmita ChakrabortyKatharina F Kubatzky
Sep 21, 2018·Frontiers in Physiology·Tabata M Dos SantosIolanda F L C Tibério

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