Gq signaling is required for allergen-induced pulmonary eosinophilia

The Journal of Immunology : Official Journal of the American Association of Immunologists
Michael T BorchersJames J Lee

Abstract

The complexity and magnitude of interactions leading to the selective infiltration of eosinophils in response to inhaled allergens are formidable obstacles to a larger understanding of the pulmonary pathology associated with allergic asthma. This study uses knockout mice to demonstrate a novel function for the heterotrimeric G protein, G(q), in the regulation of pulmonary eosinophil recruitment. In the absence of G(q) signaling, eosinophils failed to accumulate in the lungs following allergen challenge. These studies demonstrate that the inhibition of eosinophil accumulation in the airways is attributed to the failure of hemopoietically derived cells to elaborate GM-CSF in the airways. The data suggest that activation of a G(q)-coupled receptor(s) on resident leukocytes in the lung elicits expression of GM-CSF, which, in turn, is required for allergen-induced pulmonary eosinophilia, identifying a novel pathway of eosinophil-associated effector functions leading to pulmonary pathology in diseases such as asthma.

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Citations

May 30, 2002·American Journal of Respiratory Cell and Molecular Biology·David Broide
Apr 12, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christian TaubeErwin W Gelfand
Feb 6, 2020·Experimental and Therapeutic Medicine·Xiaojie RenWuhua Ma
Mar 4, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Michael T BorchersJ J Lee
Sep 27, 2005·Physiological Reviews·Nina Wettschureck, Stefan Offermanns
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