Grade 3 well-differentiated neuroendocrine tumor of the rectum: a case report

Surgical Case Reports
Misato ItoShigeki Yamaguchi

Abstract

The 2019 revised World Health Organization (WHO) classification of tumors of endocrine organs classifies grade 3 gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN G3) into well-differentiated tumors (NET G3) and poorly differentiated carcinomas (NEC G3). There are few reported cases of NET G3 occurring in the rectum. A 71-year-old man complained of bright red blood in his stool. Total colonoscopy revealed a mass in the lower rectum. Pathologic examination yielded a diagnosis of group 1. Computed tomography revealed swollen paraintestinal lymph nodes and multiple liver metastases. We performed laparoscopic abdominoperineal resection not only to avoid the unbearable symptoms caused by tumor growth but to make a pathological diagnosis. The tumor measured 3.5 × 2.8 cm, and the pathological diagnosis was stage IV neuroendocrine carcinoma. He underwent chemotherapy with irinotecan plus cisplatin, followed by carboplatin plus etopside, but his disease did not respond to either regimen. Twenty-seven months after surgery, he died of his disease. Upon re-examination of the surgical specimen, the tumor was consistent with the 2019 WHO classification of NET G3.6 CONCLUSION: A definite diagnosis of NET G3 or NEC G3 must be made to de...Continue Reading

References

Jul 29, 2010·Pancreas·Jonathan R StrosbergUNKNOWN North American Neuroendocrine Tumor Society (NANETS)
Sep 13, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H SorbyeU Knigge
Jun 27, 2015·Endocrine-related Cancer·M HeetfeldUNKNOWN other Knowledge Network members
Jan 7, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Björn KonukiewitzGünter Klöppel
Apr 30, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Susumu HijiokaNobumasa Mizuno

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Citations

Sep 10, 2021·Virchows Archiv : an International Journal of Pathology·Atsuko KasajimaGünter Klöppel

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Methods Mentioned

BETA
biopsy

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