GRADE guidelines 17: assessing the risk of bias associated with missing participant outcome data in a body of evidence

Journal of Clinical Epidemiology
Gordon H GuyattElie A Akl

Abstract

To provide GRADE guidance for assessing risk of bias across an entire body of evidence consequent on missing data for systematic reviews of both binary and continuous outcomes. Systematic survey of published methodological research, iterative discussions, testing in systematic reviews, and feedback from the GRADE Working Group. Approaches begin with a primary meta-analysis using a complete case analysis followed by sensitivity meta-analyses imputing, in each study, data for those with missing data, and then pooling across studies. For binary outcomes, we suggest use of "plausible worst case" in which review authors assume that those with missing data in treatment arms have proportionally higher event rates than those followed successfully. For continuous outcomes, imputed mean values come from other studies within the systematic review and the standard deviation (SD) from the median SDs of the control arms of all studies. If the results of the primary meta-analysis are robust to the most extreme assumptions viewed as plausible, one does not rate down certainty in the evidence for risk of bias due to missing participant outcome data. If the results prove not robust to plausible assumptions, one would rate down certainty in the e...Continue Reading

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Citations

Sep 12, 2017·The Cochrane Database of Systematic Reviews·Elie A AklHolger Schünemann
Dec 30, 2017·The Cochrane Database of Systematic Reviews·Lara A KahaleElie A Akl
Apr 7, 2018·The Cochrane Database of Systematic Reviews·Omar Abdel-RahmanHesham Elhalawani
Jun 2, 2018·The Cochrane Database of Systematic Reviews·Lara A KahaleElie A Akl
Jun 20, 2018·The Cochrane Database of Systematic Reviews·Lara A KahaleElie A Akl
Jan 25, 2018·The Cochrane Database of Systematic Reviews·Maram B HakoumElie A Akl
Jul 12, 2018·The Cochrane Database of Systematic Reviews·Charbel F MatarElie A Akl
Aug 2, 2018·Journal of Evaluation in Clinical Practice·Mathew Mercuri, Amiram Gafni
Jan 6, 2019·The Cochrane Database of Systematic Reviews·Arturo J Martí-CarvajalCristina Elena Martí-Amarista
Oct 30, 2018·Critical Care : the Official Journal of the Critical Care Forum·Bassem Y TaniosHoussam S Itani
Apr 4, 2019·The Cochrane Database of Systematic Reviews·Ning LiangJian Ping Liu
Apr 10, 2019·The Cochrane Database of Systematic Reviews·Chavdar S PavlovChristian Gluud
Jun 25, 2019·The Cochrane Database of Systematic Reviews·Ning LiangJian Ping Liu
Aug 23, 2019·The Cochrane Database of Systematic Reviews·De Zhao KongJian Ping Liu
Nov 8, 2019·The Cochrane Database of Systematic Reviews·De Zhao KongJian Ping Liu
Nov 16, 2019·Journal of General Internal Medicine·Shahnaz SultanReem A Mustafa
Nov 13, 2019·The Cochrane Database of Systematic Reviews·Joshua Z GoldenbergBradley C Johnston
Jan 25, 2020·The Cochrane Database of Systematic Reviews·Omar Abdel-Rahman, Zeinab Elsayed
Apr 15, 2020·Blood Advances·Ariel IzcovichIgnacio Neumann
Oct 26, 2018·BMC Medical Research Methodology·Loukia M SpineliHolger J Schünemann
Jun 6, 2019·BMC Cardiovascular Disorders·Federico PopoffAriel Izcovich
Aug 28, 2020·BMJ : British Medical Journal·Lara A KahaleElie A Akl
Mar 1, 2020·BMC Medical Research Methodology·Loukia M Spineli, Chrysostomos Kalyvas
Jan 16, 2021·The Cochrane Database of Systematic Reviews·Sadia JanjuaSofia Dias
Feb 2, 2021·SN Comprehensive Clinical Medicine·Zinat Nadia Hatmi
Jul 7, 2021·The Cochrane Database of Systematic Reviews·Delia HornRoger Soll
Jul 14, 2021·Zeitschrift für Evidenz, Fortbildung und Qualität im Gesundheitswesen·Olesja RisslingLukas Schwingshackl
Aug 26, 2021·The Cochrane Database of Systematic Reviews·Milica BjelakovicChristian Gluud
Sep 14, 2021·The Cochrane Database of Systematic Reviews·Vor LuviraPorjai Pattanittum
Sep 29, 2021·The Cochrane Database of Systematic Reviews·Lara A KahaleElie A Akl

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