Grade of Cataract and Its Influence on Measurement of Macular Pigment Optical Density Using Autofluorescence Imaging

Investigative Ophthalmology & Visual Science
Akira ObanaPaul S Bernstein

Abstract

To evaluate the influence of cataracts on measuring macular pigment optical density (MPOD) using a dual-wavelength confocal scanning autofluorescence imaging technique and to establish methods to compensate for the influence of cataracts. This prospective case series comprised 100 eyes that underwent cataract surgery. Cataracts were graded based on the World Health Organization classification. MPOD levels were measured with the MPOD module of the Spectralis MultiColor instrument (Spectralis-MP), pre- and postoperatively. We investigated the relationship between change in MPOD values and age, cataract grade, and quality of autofluorescence images. Local MPOD levels were evaluated for four strategically chosen eccentricities within the macular region, and the total MPOD volume was evaluated within 8.98° eccentricity from the center. MPOD levels could be obtained in 67 eyes before surgery. Local and volume MPOD levels were higher postoperatively relative to preoperatively in all eyes. The mean ratio of local MPOD levels after and before surgery (correction factor, CF) ranged from 1.42 to 1.77, with larger CFs required for eccentricities closer to the foveal center. The CF for the MPOD volume was 1.31. Age, grade of nuclear catarac...Continue Reading

References

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Oct 2, 2013·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Raymond O Beirne
Mar 15, 2014·Investigative Ophthalmology & Visual Science·Kumari NeelamKah-Guan Au Eong
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May 11, 2016·Investigative Ophthalmology & Visual Science·Kwadwo Owusu AkuffoStephen Beatty
Jul 21, 2017·Investigative Ophthalmology & Visual Science·Christopher D ConradyPaul S Bernstein

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Citations

May 16, 2019·Annual Review of Nutrition·Lydia SauerPaul S Bernstein
Jan 29, 2020·Japanese Journal of Ophthalmology·Akira ObanaPaul S Bernstein
Dec 24, 2019·Translational Vision Science & Technology·Marina Green-GomezJohn M Nolan
Jun 30, 2019·Scientific Reports·Akira ObanaPaul S Bernstein
Apr 17, 2019·Experimental Eye Research·Yao WangSandra R Montezuma
May 19, 2021·Translational Vision Science & Technology·Akira ObanaHidenao Yamada

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Software Mentioned

Spectralis
MP

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