Graded and discontinuous EphA-ephrinB expression patterns in the developing auditory brainstem

Hearing Research
Matthew M WallaceM L Gabriele

Abstract

Eph-ephrin interactions guide topographic mapping and pattern formation in a variety of systems. In contrast to other sensory pathways, their precise role in the assembly of central auditory circuits remains poorly understood. The auditory midbrain, or inferior colliculus (IC) is an intriguing structure for exploring guidance of patterned projections as adjacent subdivisions exhibit distinct organizational features. The central nucleus of the IC (CNIC) and deep aspects of its neighboring lateral cortex (LCIC, Layer 3) are tonotopically-organized and receive layered inputs from primarily downstream auditory sources. While less is known about more superficial aspects of the LCIC, its inputs are multimodal, lack a clear tonotopic order, and appear discontinuous, terminating in modular, patch/matrix-like distributions. Here we utilize X-Gal staining approaches in lacZ mutant mice (ephrin-B2, -B3, and EphA4) to reveal EphA-ephrinB expression patterns in the nascent IC during the period of projection shaping that precedes hearing onset. We also report early postnatal protein expression in the cochlear nuclei, the superior olivary complex, the nuclei of the lateral lemniscus, and relevant midline structures. Continuous ephrin-B2 and E...Continue Reading

References

May 15, 1992·The Journal of Comparative Neurology·E Saldaña, M A Merchán
Aug 8, 1987·The Journal of Comparative Neurology·J R Coleman, W J Clerici
Feb 8, 1993·The Journal of Comparative Neurology·K Kandler, E Friauf
Dec 16, 1996·The Journal of Comparative Neurology·S J Shammah-LagnadoL Heimer
Jul 24, 1997·Nature·C E Schreiner, G Langner
Oct 23, 1997·Current Opinion in Cell Biology·E B Pasquale
Apr 29, 1998·Hearing Research·L M Bianchi, N W Gale
Mar 10, 2001·Nature·P A LeightonM Tessier-Lavigne
Jul 13, 2002·The Journal of Comparative Neurology·James O PicklesWalter R A Van Heumen
Sep 3, 2002·The Journal of Comparative Neurology·Karina S CramerEdwin W Rubel
Dec 18, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Lynne M BianchiNicholas W Gale
May 23, 2003·The Journal of Comparative Neurology·Dominik BrorsAllen F Ryan
Feb 5, 2004·Hearing Research·Michelle L ChernockJeffery A Winer
Mar 17, 2004·Current Opinion in Neurobiology·Scott E WilliamsEloísa Herrera
Jun 10, 2004·Journal of Neurobiology·Abigail L PersonKarina S Cramer
Jun 29, 2004·Trends in Neurosciences·Pierre Vanderhaeghen, Franck Polleux
Jun 30, 2004·Developmental Biology·Christopher DravisMark Henkemeyer
Aug 28, 2004·Trends in Neurosciences·Sonia Garel, John L R Rubenstein
Jul 19, 2005·Annual Review of Neuroscience·Todd McLaughlin, Dennis D M O'Leary
Aug 6, 2005·Hearing Research·Karina S Cramer
Aug 11, 2005·Hearing Research·Jeffery A Winer
Jan 18, 2006·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Daniela UzielJürgen Bolz
Jan 25, 2006·The Journal of Comparative Neurology·Jianxun Zhou, Susan Shore
Mar 4, 2006·Hearing Research·Susan E Shore, Jianxun Zhou
Jun 30, 2006·Seminars in Cell & Developmental Biology·Jörg Strotmann, Heinz Breer
Jun 20, 2007·Developmental Neurobiology·Kelly J Huffman, Karina S Cramer
Oct 24, 2007·The Journal of Comparative Neurology·Ilona J MikoKarina S Cramer
Oct 30, 2007·Neuron·Liqun Luo, John G Flanagan
Oct 31, 2007·Hearing Research·Ilona J MikoKarina S Cramer

❮ Previous
Next ❯

Citations

Aug 9, 2017·The Journal of Comparative Neurology·Christopher H DillinghamMark L Gabriele
Nov 16, 2019·Brain Structure & Function·Isabel D Lamb-EchegarayMark L Gabriele
Jan 31, 2019·Annual Review of Neuroscience·Nicolas Michalski, Christine Petit
Apr 6, 2021·Frontiers in Neuroanatomy·Jeremiah P C StinsonMark L Gabriele

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allen Institute for Brain Science Network

The Allen Institute for Brain Science Network is a not-for-profit biomedical research organization that provides open access to multiple neuroscience tools and resources. Find the latest research from tjr Allen Institute for Brain Science Network here.