Graded Cerebellar Lobular Volume Deficits in Adolescents and Young Adults with Fetal Alcohol Spectrum Disorders (FASD).

Cerebral Cortex
Edith V SullivanAdolf Pfefferbaum

Abstract

The extensive prenatal developmental growth period of the cerebellum renders it vulnerable to unhealthy environmental agents, especially alcohol. Fetal alcohol spectrum disorders (FASD) is marked by neurodysmorphology including cerebral and cerebellar volume deficits, but the cerebellar lobular deficit profile has not been delineated. Legacy MRI data of 115 affected and 59 unaffected adolescents and young adults were analyzed for lobular gray matter volume and revealed graded deficits supporting a spectrum of severity. Graded deficits were salient in intracranial volume (ICV), where the fetal alcohol syndrome (FAS) group was smaller than the fetal alcohol effects (FAE) group, which was smaller than the controls. Adjusting for ICV, volume deficits were present in VIIB and VIIIA of the FAE group and were more widespread in FAS and included lobules I, II, IV, V, VI, Crus II, VIIB, and VIIIA. Graded deficits (FAS < FAE) were consistently present in lobules VI; neither group showed volume deficits in Crus I or IX. Neuroradiological readings blind to diagnosis identified 20 anomalies, 8 involving the cerebellum, 5 of which were in the FAS group. We speculate that the regional cerebellar FASD-related volume deficits may contribute to ...Continue Reading

References

Jan 1, 1978·The Journal of Pediatrics·S K ClarrenD W Smith
Feb 1, 1990·Alcoholism, Clinical and Experimental Research·D J Bonthius, J R West
Feb 1, 1996·Alcoholism, Clinical and Experimental Research·E R SowellK L Jones
Feb 11, 1997·Pediatrics·V W SwayzeN C Andreasen
May 15, 1998·Alcoholism, Clinical and Experimental Research·T M RoebuckE P Riley
Jul 19, 2002·The Anatomical Record·Fred L BooksteinAnn P Streissguth
Mar 15, 2005·Brain Research. Developmental Brain Research·Krikor DikranianJohn W Olney
May 6, 2005·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Joan M CoffinJoshua O'Neill
Jun 16, 2005·Experimental Biology and Medicine·Kathleen K Sulik
Aug 2, 2005·Neuroreport·Elizabeth D O'HareElizabeth R Sowell
Sep 7, 2006·The Anatomical Record. Part B, the New Anatomist·Fred L BooksteinPaul D Sampson
May 18, 2007·Annual Review of Cell and Developmental Biology·Roy V Sillitoe, Alexandra L Joyner
Dec 29, 2007·Alcoholism, Clinical and Experimental Research·Sandra W JacobsonJoseph L Jacobson
Feb 25, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Dharmendra GanesanDominic N Thompson
May 22, 2009·NeuroImage·Jörn DiedrichsenNarender Ramnani
Jul 4, 2009·Alcoholism, Clinical and Experimental Research·Susan J AstleyTodd Richards
Jul 14, 2009·Cerebral Cortex·Fenna M Krienen, Randy L Buckner
Aug 19, 2009·BMJ : British Medical Journal·Zoe MorrisRustam Al-Shahi Salman
Sep 5, 2009·Developmental Disabilities Research Reviews·Andria L NormanEdward P Riley
Dec 18, 2009·Human Brain Mapping·Torsten RohlfingAdolf Pfefferbaum
Feb 16, 2010·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Catherine J Stoodley, Jeremy D Schmahmann
Sep 22, 2010·Neuropsychiatric Disease and Treatment·Elizabeth Peadon, Elizabeth J Elliott
Mar 23, 2011·Developmental Medicine and Child Neurology·Marie-Eve BolducCatherine Limperopoulos
Sep 9, 2011·The Cerebellum·Marie-Eve BolducCatherine Limperopoulos
Sep 13, 2011·NeuroImage·Catherine J StoodleyJeremy D Schmahmann
Nov 2, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Catherine LebelElizabeth R Sowell
Nov 6, 2012·Human Brain Mapping·Keren-Happuch EJohn E Desmond
Nov 14, 2012·Cerebral Cortex·Catherine LimperopoulosAdré J du Plessis
Jul 3, 2013·AJNR. American Journal of Neuroradiology·R E GurR C Gur
Dec 4, 2013·Journal of the American Medical Informatics Association : JAMIA·Torsten RohlfingB Nolan Nichols
Nov 19, 2014·Brain Imaging and Behavior·Drew KaiserUNKNOWN Cincinnati MR Imaging of NeuroDevelopment (CMIND) Authorship Consortium
Apr 24, 2015·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Ernesto Roldan-ValadezCamilo Rios

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Citations

Jun 29, 2021·Frontiers in Molecular Biosciences·Iskra AraujoDanielle Gulick
Aug 28, 2021·International Journal of Environmental Research and Public Health·Hiroshi MitomaAasef G Shaikh

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