Graded inhibition of retrograde axonal transport by compression of rabbit vagus nerve

Journal of the Neurological Sciences
L B DahlinW G McLean

Abstract

Effects of experimental compression at different pressures on retrograde axonal transport were studied in rabbit vagus nerve. Proteins in the sensory neurones were radiolabelled by injection of [3H]leucine into the nodose ganglion. Sixteen hours after labelling, a small compression chamber and/or ligatures were applied around the cervical part of the vagus nerve for 8 h. Compression of the vagus nerve at 20, 30 and 200 mm Hg pressure induced a graded inhibition of both retrograde and anterograde transport of the radiolabelled proteins. Neither retrograde nor anterograde transport was affected by the presence of the non-inflated chamber. The results indicate that compression at pressures similar to those found in human carpal tunnel syndrome can block retrograde axonal transport. The consequences of inhibition of retrograde and anterograde axonal transport for the metabolism in the nerve cell bodies are discussed.

References

Jun 1, 1976·Journal of Neurochemistry·W G McLeanJ Sijöstrand
Aug 1, 1977·Journal of Neurochemistry·M A Bisby, V T Bulger
Sep 1, 1975·Experimental Neurology·B Grafstein
Jan 1, 1986·Journal of the Neurological Sciences·L B Dahlin, W G McLean
Oct 1, 1987·Experimental Neurology·B Arvidson
Jun 1, 1985·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·L C HurstR E Carroll
May 1, 1985·Neuropathology and Applied Neurobiology·A B Sterman, N Sposito
Jan 1, 1969·Journal of Neurobiology·S Ochs, N Ranish
Aug 18, 1973·Lancet·A R Upton, A J McComas
Sep 29, 1970·Brain Research·B G Cragg
Jul 1, 1982·La Tunisie médicale·F LetaifR Boukhris
Aug 1, 1980·Journal of Neurology, Neurosurgery, and Psychiatry·B RydevikG Lundborg
May 1, 1983·Journal of Neurobiology·W G McLeanJ Sjöstrand
Feb 1, 1983·Muscle & Nerve·J JakobsenP Sidenius
Apr 1, 1984·Experimental Neurology·L B DahlinJ Sjöstrand
Nov 1, 1984·Journal of Neurochemistry·M S Miller, P S Spencer
Jul 1, 1982·Neuropathology and Applied Neurobiology·J B Cavanagh
Mar 1, 1983·Journal of Neuropathology and Experimental Neurology·A B Sterman
Feb 1, 1981·American Journal of Surgery·D S StrayerR Bresalier
Dec 23, 2003·Neuron·Shlomit HanzMike Fainzilber

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Citations

Jun 1, 1992·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·G Lundborg
Feb 1, 1993·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·L B DahlinW G McLean
Jun 1, 1996·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·M TanoueK Takagi
Mar 17, 2004·Magnetic Resonance Imaging Clinics of North America·Jeffrey A Stone
Dec 1, 2001·Neuroreport·M BergmarkL B Dahlin
Sep 24, 2004·The European Journal of Neuroscience·L M E PetterssonN Danielsen
Feb 2, 2012·The Journal of Manual & Manipulative Therapy·Cynthia L BrownMichael P Smith
Jun 3, 2004·Magnetic Resonance Imaging Clinics of North America·Marcelo Bordalo-Rodrigues, Zehava Sadka Rosenberg
Oct 19, 2016·The Journal of Hand Surgery·Brian H CohenPatrick M Kane
Oct 30, 2014·The Open Orthopaedics Journal·Vanitha ArumugamJoy C MacDermid
Jul 15, 2003·The International Journal of Neuroscience·Levent Sarikcioglu, Olcay Ozkan
Jan 1, 1992·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·L B Dahlin, M Kanje
Nov 27, 2001·The Journal of Hand Surgery·R GuptaN F Jones

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