PMID: 1197390Jul 1, 1975Paper

Graded levels of hemorrhage, thirst and angiotensin II in the rat

Physiology & Behavior
P J RussellG J Mogenson

Abstract

Hemorrhage was evaluated as a stimulus to drink in rats prepared with chronically implanted jugular cannulae and bled either 20, 30, 40 or 50 percent of their total blood volume. Hourly observations of water intake for 5 hr after hemorrhage revealed that the volume drunk was proportional to the degree of hemorrhage. Drinking induced by 20 percent hemorrhage did not differ significantly from control values, and intake was greatest and most persistent after 50 percent blood loss. The onset of maximal drinking at 1 hr after 40 percent hemorrhage was preceded by a twofold increase in plasma concentrations of angiotensin II. This is compatible with previous suggestions that angiotensin plays a role in hypovolemic thirst.

References

Jan 1, 1971·The Journal of Clinical Investigation·M D BailieD W Seldin
Nov 1, 1936·The Journal of Clinical Investigation·J D Stewart, G M Rourke

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Citations

Aug 1, 1978·Physiology & Behavior·J W WrightK Donlon
Jan 1, 1988·Physiology & Behavior·P JanczewskiE Szczepanska-Sadowska
Jan 1, 1979·Acta Physiologica Scandinavica·B Holstein
Aug 1, 2014·Clinical Journal of the American Society of Nephrology : CJASN·John Danziger, Mark L Zeidel
Nov 14, 2017·Nature Reviews. Nephrology·Claire Gizowski, Charles W Bourque
May 29, 2010·Prehospital Emergency Care : Official Journal of the National Association of EMS Physicians and the National Association of State EMS Directors·Robert T GerhardtGwendolyn M Mueller

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