PMID: 9658593Jul 11, 1998Paper

Gradient in convergent cell movement during Fundulus gastrulation

The Journal of Experimental Zoology
J P TRINKAUS

Abstract

This contribution represents a continuation of our studies of a gradient in convergent cell movement in the germ ring (GR) during Fundulus gastrulation (Trinkaus et al. [1992] J. Exp. Zool., 261:40-61). In our previous study, we discovered that cells in the dorsal GR nearest the embryonic shield (ES) move toward the ES at a net faster rate than those farther away and that this is due to less meandering. Those farther away meander more. These data suggest the hypothesis that there is a gradient of cues that direct cells to the ES. If so, cells in the ventral GR, farthest from the ES, should meander even more and hence show little or no convergence toward the ES. To test this hypothesis, we have traced the trajectories of individual cells in the midventral GR during midepiboly and have found that, although the general motile behavior of ventral GR cells is the same as that of dorsal cells, they do indeed meander much more and, as a result, show little or no directional movement toward the ES. Taken together, these results indicate that cells of the germ ring move up a gradient in directionality as they converge toward their target, the embryonic shield. One possible explanation for this is that the embryonic shield attracts cells...Continue Reading

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Citations

Jul 10, 2002·Nature Cell Biology·Jason R JessenLilianna Solnica-Krezel
Apr 21, 2016·Zebrafish·Kyle Anorve-AndressJennifer Ostrom Liang
Aug 16, 2005·Current Opinion in Cell Biology·Ray Keller
Sep 19, 2000·Genesis : the Journal of Genetics and Development·D S SepichL Solnica-Krezel
Feb 21, 2013·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Sirilak ChuaypanangRobert L Preston
Aug 30, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Diane S SepichLila Solnica-Krezel
Feb 16, 2002·Developmental Biology·Dina C MyersLilianna Solnica-Krezel
Aug 15, 2002·Trends in Genetics : TIG·Dina C MyersLilianna Solnica-Krezel
Jun 14, 2002·Developmental Cell·John B WallingfordRichard M Harland
Apr 16, 2003·Differentiation; Research in Biological Diversity·Ray KellerDavid R Shook
Mar 31, 2005·Current Biology : CB·Lilianna Solnica-Krezel
Dec 12, 2007·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Karen G BurnettDouglas L Crawford
Mar 28, 2009·Mechanisms of Development·Yasuhiro TonoyamaShogo Oka

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