Gradual tapering of desmopressin leads to better outcome in nocturnal enuresis

Pediatrics International : Official Journal of the Japan Pediatric Society
Yoshiyuki OhtomoToshiaki Shimizu

Abstract

Although desmopressin therapy is effective in treating polyuric monosymptomatic nocturnal enuresis (MNE), the relatively high rates of recurrence are problematic. To date, the treatment protocol on the discontinuation of oral desmopressin melt (ODM) tablet, MinirinMelt, has not been established. We tested two protocols of tapering ODM when the patients achieved full response on ODM, and compared the treatment outcomes. One hundred and fifty-seven polyuric MNE children were newly treated with ODM at the authors' outpatient clinics (Juntendo Nerima Hospital and Musashi-Murayama Hospital). When the patients did not respond to the 8 week ODM therapy, we added another options such as alarm, anti-cholinergics, and imipramine (92 patients; 58.6%). Sixty-five patients (41.4%) achieved full response on ODM alone, and 49 of them accepted gradual tapering of ODM: group B (n = 25), 240 μg ODM per day → 120 μg ODM per day → 120 μg ODM per alternate day → cessation; and group C (n = 24), 240 μg ODM per day → 120 μg ODM per day → 60 μg ODM per day → 60 μg ODM per alternate day → cessation. Fourteen patients in group B (56%) and four in group C (17%) had relapses of enuresis after the discontinuation of ODM (P = 0.026). Gradual tapering of ODM...Continue Reading

References

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Aug 22, 2009·The Journal of Urology·Daniela Marschall-KehrelUNKNOWN Enuresis Algorithm of Marschall Survey Group
Dec 17, 2009·The Journal of Urology·Tryggve NeveusUNKNOWN International Children's Continence Society
Mar 1, 2012·European Journal of Pediatrics·Johan Vande WalleUNKNOWN International Children’s Continence Society
Jun 19, 2013·Pediatrics International : Official Journal of the Japan Pediatric Society·Yoshiyuki OhtomoToshiaki Shimizu
Jun 25, 2013·Journal of Pediatric Urology·Pietro FerraraAntonio Chiaretti

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Citations

Apr 14, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Konstantinos KamperisJohan Vande Walle
Oct 12, 2018·Pediatric Annals·Linda S NieldOulimata K Grossman
Jun 9, 2020·Paediatric Drugs·Elke GasthuysJohan Vande Walle
Mar 21, 2017·Pediatrics International : Official Journal of the Japan Pediatric Society·Shuichiro FujinagaYoshiyuki Ohtomo
Jun 28, 2016·Pediatrics·Michael E ChuaStephen S Yang

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