Graft inflammation and histologic indicators of kidney chronic allograft failure: low-expressing interleukin-10 genotypes cannot be ignored

Transplantation
Faisal KhanNoureddine Berka

Abstract

Infiltration of inflammatory cells into the renal allograft interstitium is the biologic hallmark of alloimmune responses that leads to tubulointerstitial injury and subsequent interstitial fibrosis and chronic allograft failure. The proliferation, stimulation, and infiltration of these inflammatory cells are governed by various proinflammatory and regulatory cytokines. We assessed whether the differences in the genes encoding cytokines (producing low, moderate, or high expression profiles) may affect the infiltration of inflammatory cells into the renal allograft and the histologic changes characteristics of chronic allograft failure. A total of 218 kidney transplant recipients were genotyped for 15 single-nucleotide polymorphisms located in the gene promoter or exonic regions of 10 different cytokines or their receptors. Six- to 12-month posttransplant surveillance biopsies were scored using 11 individual histologic parameters and the combined grade of interstitial fibrosis and tubular atrophy (IF/TA). B-cell, T-cell, and macrophage infiltrates were quantified by immunostaining. The low-expressing interleukin (IL)-10 gene promoter genotypes were found significantly associated with high IF/TA grade (IL-10 -819 TT; P=0.035; odd...Continue Reading

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Citations

Mar 28, 2012·Current Opinion in Nephrology and Hypertension·Alton B Farris, Robert B Colvin
Jul 26, 2012·Transplantation·Ajda Tahereh Rowshani, Elly Johanna Francisca Vereyken
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Apr 6, 2013·Cytokine·Ana Paula Lucas MotaLuci Maria Dusse
Aug 19, 2020·Immunologic Research·Lorraine Vieira AlvesAna Paula Lucas Mota

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