Graft options in posterolateral and posterior interbody lumbar fusion

Spine
Jeffrey A RihnTodd J Albert

Abstract

Review article, review of literature. To review the bone graft options that exist for posterolateral and posterior interbody lumbar fusion. As the number of lumbar fusion surgeries has increased over the last decade, alternative methods of grafting have been developed. Iliac crest autograft bone has traditionally been used for lumbar fusion. The downside to this graft option, however, is donor site morbidity. The current literature on alternatives to iliac crest autograft bone for obtaining lumbar fusion was reviewed. Platelet gels, demineralized bone matrix, synthetic bone graft, and bone morphogenetic protein are potential options for bone graft supplementation or substitution. In preclinical studies, platelet gels have been beneficial to bone growth when combined with autograft, but clinical studies do not support the use of platelet gel in posterolateral lumbar fusion. Preclinical studies of demineralized bone matrix have shown significant variability in the osteoinductive properties of the available products, and clinical data showing efficacy is limited. The use of synthetic bone graft material (ceramics) in lumbar fusion surgery is increasing. Calcium phosphate compounds (i.e., beta-tricalcium phosphate and hydroxyapetit...Continue Reading

References

Jan 1, 1990·Journal of Cell Science. Supplement·J M WozneyE A Wang
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A J CelesteJ M Wozney
Aug 1, 1989·The Journal of Bone and Joint Surgery. British Volume·B N Summers, S M Eisenstein
Jan 1, 1989·Journal of Orthopaedic Trauma·E M Younger, M W Chapman
Nov 12, 1965·Science·M R Urist
Apr 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T AikawaT Matsuya
Jun 1, 1997·Clinical Orthopaedics and Related Research·J A GouletM L Greenfield
Feb 10, 2000·The Journal of the American Academy of Orthopaedic Surgeons·D A ZlotolowT J Albert
May 11, 2002·The Journal of Bone and Joint Surgery. American Volume·Elke AhlmannPaul Holtom
Oct 24, 2002·Journal of Spinal Disorders & Techniques·J Kenneth BurkusThomas A Zdeblick
Aug 20, 2003·The Journal of Bone and Joint Surgery. American Volume·Hongwei ChengTong-Chuan He
Nov 1, 2003·The Spine Journal : Official Journal of the North American Spine Society·Bryan W CunninghamPaul C McAfee
Mar 23, 2004·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·William R WalshR M Gillies
Sep 24, 2004·Journal of Spinal Disorders & Techniques·Frank P Castro
Oct 7, 2004·The Journal of Bone and Joint Surgery. American Volume·Brett PetersonJay R Lieberman
Jan 27, 2005·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Alexander R VaccaroTodd J Albert
Feb 9, 2005·Journal of Spinal Disorders & Techniques·James D SchwenderKevin T Foley
Dec 31, 2005·Journal of Neurosurgery. Spine·Alan T VillavicencioJeffrey Thramann

❮ Previous
Next ❯

Citations

Jul 11, 2012·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Jesper Roed SørensenSøren Overgaard
Feb 27, 2013·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Charla R FischerThomas Errico
May 4, 2012·Science Translational Medicine·Suzanne ZeitouniCarl A Gregory
Jun 7, 2012·Journal of Pediatric Orthopedics. Part B·Daniel J Westacott, Stephen J Cooke
Jan 12, 2013·The Spine Journal : Official Journal of the North American Spine Society·Josh NemanRahul Jandial
Jul 7, 2011·The Spine Journal : Official Journal of the North American Spine Society·Jeffrey C Wang
Jun 1, 2015·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Katsuhisa YamadaNorimasa Iwasaki
Sep 3, 2013·Journal of Tissue Engineering and Regenerative Medicine·Akishige HokugoReza Jarrahy
Apr 20, 2011·Journal of Cellular Biochemistry·Jared S JohnsonFarhad Parhami
Mar 5, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Scott R MontgomeryFarhad Parhami
Aug 19, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Bret H CloughCarl A Gregory
Apr 8, 2015·Musculoskeletal Surgery·A M JakoiP J Cahill
Apr 22, 2011·Biomaterials·Joel D BoerckelRobert E Guldberg
Mar 20, 2012·The Spine Journal : Official Journal of the North American Spine Society·Rene Olivares-NavarreteBarbara D Boyan
Aug 30, 2014·Neurologia Medico-chirurgica·Motohiro HirasawaShinji Nagahiro
May 16, 2015·Journal of Spinal Disorders & Techniques·Abhishek KannanWellington K Hsu
Mar 6, 2013·World Neurosurgery·Daniel Lubelski, Edward C Benzel
Dec 3, 2014·The Spine Journal : Official Journal of the North American Spine Society·Trevor P ScottFarhad Parhami
Jan 21, 2015·Der Orthopäde·K-M Scheufler, D Diesing
Mar 3, 2015·The Spine Journal : Official Journal of the North American Spine Society·Dexter K BatemanAlexander R Vaccaro
Oct 22, 2016·The Spine Journal : Official Journal of the North American Spine Society·Bret H CloughCarl A Gregory
Feb 21, 2013·International Journal of Toxicology·Paul O ZamoraXinhua Lin
Mar 22, 2014·World Journal of Orthopedics·Konstantinos TilkeridisGeorgios I Drosos
Jan 8, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Lukas A van DijkJoost D de Bruijn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.