Graft rejection rate and graft failure rate of penetrating keratoplasty (PKP) vs lamellar procedures: a systematic review

PloS One
Zarique Z AkandaWilliam G Hodge

Abstract

The aim of our investigation was to conduct a quantitative meta-analysis of the present world literature comparing the major surgical outcomes of penetrating keratoplasty (PKP) to lamellar procedures. Our goal is that clinicians, eye bank administrators, and health policy makers will be able to utilize this study in implementing decisions in regards to corneal transplantation. Pooled measures of association were with odds ratios and because of study heterogeneity, the pooled effects were assumed to follow a random effects model (DerSimonian-Laird). The comparisons were between 1) PKP's and all lamellar procedures (anterior AND posterior) and then 2) between PKP's and all anterior lamellar procedures and 3) PKP and all posterior lamellar procedures. For PKP vs anterior lamellar procedures, the pooled odds ratio for rejection of PKP over lamellar keratoplasty (LK) was 3.56 (95% CI: 1.76-7.20) and for outright failure, the pooled odds ratio of PKP failure vs LK was 2.85 (95% CI: 0.84-9.66). For posterior lamellar procedures, the pooled odds ratio for rejection of PKP over LK was 1.52 (95% CI: 1.00-2.32). The pooled odds ratio for outright failure of PKP over posterior lamellar procedures was 2.09 (95% CI: 0.57-7.59). The follow up...Continue Reading

References

Aug 17, 2001·Current Opinion in Ophthalmology·S Jain, D T Azar
Dec 13, 2001·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·F TrimarchiC Piacentini
Jul 26, 2002·American Journal of Ophthalmology·Jun ShimazakiKazuo Tsubota
Jul 18, 2003·Ophthalmology·Robert W ThompsonFrancis W Price
Oct 30, 2004·Seminars in Ophthalmology·T Senoo
Apr 25, 2006·Journal of Cataract and Refractive Surgery·Francis W Price, Marianne O Price
Aug 1, 2006·American Journal of Ophthalmology·Motoko KawashimaJun Shimazaki
Sep 26, 2007·Cornea·Bruce D S AllanMargareta Claesson
Dec 7, 2007·Ophthalmology·Donald T H TanLaurence S Lim
Jan 16, 2008·Archives of Ophthalmology·Vincent M BorderieLaurent Laroche
Jul 11, 2009·American Journal of Ophthalmology·Daphne C Y HanDonald T H Tan
Aug 8, 2009·Investigative Ophthalmology & Visual Science·Mark N A JonesUNKNOWN NHSBT Ocular Tissue Advisory Group and Contributing Ophthalmologists (OTAG Audit Study 5)
Oct 10, 2009·Ophthalmology·Vincent M BorderieLaurent Laroche
Jan 30, 2010·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·R CeccuzziP E Bianchi
Sep 11, 2010·The British Journal of Ophthalmology·D T H TanH M Htoon
Nov 8, 2011·Ophthalmology·Vincent M BorderieLaurent Laroche
Dec 27, 2011·Ophthalmology·Michael RudolphFriedrich E Kruse
May 9, 2012·Lancet·Donald T H TanShigeru Kinoshita
Feb 27, 2013·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Dermot CassidyMichael S Loughnan
Nov 26, 2013·Cornea·Mark S Gorovoy

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Citations

Mar 25, 2017·PloS One·Suneel GuptaRajiv R Mohan
Jul 23, 2019·Journal of Biomedical Materials Research. Part a·Jing LiuZuguo Liu
Aug 9, 2020·European Journal of Ophthalmology·Yumna Busool Abu EtaRaneen Shehadeh Mashour
Aug 8, 2020·European Journal of Ophthalmology·Andrea MonteselJorge L Alió
Dec 21, 2020·Journal of Cellular and Molecular Medicine·Shenyang LiJiansu Chen
Feb 9, 2021·American Journal of Ophthalmology·Eric J ShiueyZeba A Syed
Dec 6, 2020·Journal of Cataract and Refractive Surgery·Suryan L DunkerMor M Dickman
Aug 6, 2021·Cornea·Gilad LitvinAbraham Nyska
Aug 14, 2021·International Ophthalmology·Merve Beyza Yıldız, Elvin Yıldız

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