PMID: 2487434Jan 1, 1989Paper

Graft-versus-host disease associated with transfusions. Detection of 2 cases by skin biopsy in children

Medicina
R Drut, R M Drut

Abstract

The first case was a 2 year-old girl with Blackfan-Diamond anemia who developed the immune reaction two weeks after receiving two transfusions of sedimented erythrocytes. HLA typing of lymphocytes showed the presence of three HLA-A, two of which were present in the donors. The second was a newborn who initially received an exchange transfusion and three weeks later another transfusion of whole blood. Both cases exhibited a severe bone marrow involvement and a skin biopsy with the pattern of keratinocyte apoptosis and lymphocyte satellitosis. These histological findings although highly suggestive must be evaluated in the appropriate clinical setting.

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