Jan 1, 1985

Graft-versus-host disease in rhabdomyosarcoma following transfusion with nonirradiated blood products

Medical and Pediatric Oncology
R J Labotka, R Radvany


Graft-versus-host disease is a complication of transfusion of nonirradiated blood products into an immunocompromised patient, and it has been reported in hematologic and lymphoid malignancies as well as in neuroblastoma in children. We report the first case of acute graft-versus-host disease in a child undergoing chemotherapy for a rhabdomyosarcoma, who received transfusions during an intercurrent illness. The graft-versus-host disease was accompanied by an allogeneic lymphoid graft and was diagnosed on the basis of HLA studies on the patient's and her family's circulating lymphocytes and confirmed by HLA typing of the patient's skin fibroblasts.

  • References7
  • Citations7


Mentioned in this Paper

Cancer of Nasopharynx
Blood product
Hematology (Discipline)
Central Neuroblastoma
Specimen Type - Fibroblasts
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Acute GVH Disease
Graft-vs-Host Disease
HLA Antigens
Graft-Versus-Host Disease Pathway

About this Paper

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.