PMID: 8839556Oct 1, 1996

Graft-versus-host disease. Possible higher risk for African American patients

Cancer
S J EasawT Ahmed

Abstract

Race is not generally recognized as a factor in the severity or incidence of graft-versus-host disease (GVHD) after allogeneic bone marrow transplantation. The impression that African American patients had more frequent and severe GVHD prompted this retrospective survey. The records of 75 consecutive patients treated with a human leukocyte antigen-identical sibling bone marrow transplant from 1985 to 1993 were reviewed. GVHD prophylaxis uniformly employed cyclosporine and steroids. Treatment of GVHD included cyclosporine and high dose steroids in all cases. Antithymocyte globulin and other immunosuppressants were used in severe cases. Of 75 patients, 56 (75%) were white, 11 (15%) were listed as "Hispanic", 7 (9%) were African Americans, and 1 was of Far-Eastern origin. Four of the African American patients had chronic myelogenous leukemia and 2 had acute leukemia, whereas 21 of the other 68 patients (31%) had chronic myelogenous leukemia, 31 (46%) had acute leukemia, and the remainder (33%) had miscellaneous hematologic malignancies. Transplants from a female donor to a male recipient were performed in 2 of 7 African Americans and 19 of 68 patients (28%) of other origins. Five of the 6 evaluable African American patients (83%; ...Continue Reading

Citations

Dec 1, 1978·Annals of Internal Medicine·C D BucknerE D Thomas
Apr 17, 1975·The New England Journal of Medicine·E D ThomasC D Buckner
Feb 1, 1991·Tissue Antigens·T D LeeW X Shi
Sep 13, 1990·The New England Journal of Medicine·K M SullivanR P Witherspoon
Apr 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E J FortenberyW E Duncan
Mar 30, 1989·The New England Journal of Medicine·K M SullivanJ A Hansen
Oct 1, 1988·Transplantation·L BoströmB Nilsson
Feb 28, 1987·Lancet·J W GratamaJ Vossen
Dec 1, 1987·British Journal of Haematology·R P GaleJ H Kersey

Related Concepts

Other immunosuppressants in ATC
Hematologic Neoplasms
Acute Leukemia
Restasis
African Continental Ancestry Group
Graft-vs-Host Disease
Bone Marrow
Cyclosporine
Severity of Illness Index
HLA Antigens

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.