Graft versus Host Disease Presenting as Fibrosing Alopecia in a Pattern Distribution: A Model for Pathophysiological Understanding of Cicatricial Pattern Hair Loss

International Journal of Trichology
Hudson Dutra RezendeRalph Michel Trüeb

Abstract

A case of cutaneous graft versus host disease (GvHD) presenting as fibrosing alopecia in a pattern distribution (FAPD) is discussed, possibly providing a mechanistic model for a better understanding of the pathogenic events underlying cicatricial pattern hair loss. The implication of a follicular inflammation and fibrosis associated with patterned hair loss has emerged from several independent studies. Eventually, Zinkernagel and Trüeb reported a peculiar type of cicatricial pattern hair loss with histopathological features consistent with lichen planopilaris (LPP) associated with androgenetic alopecia (AGA). With regard to its pathogenesis, LPP is regarded to constitute a T-cell-mediated autoimmune reaction. An as yet unknown antigenic stimulus from the malfunctioning hair follicle may initiate a lichenoid tissue reaction that triggers apoptosis of the follicular epithelial cells in the susceptible individual. GvHD is a complication following allogeneic tissue transplantation and is induced and maintained by immunocompetent cells from the donor tissue that particularly attack epithelia of fast-proliferating tissues in the recipient. Due to its analogies with lichen planus, GvHD constitutes a valid immunologic model for lichen ...Continue Reading

References

Apr 29, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S EichmüllerR Paus

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Citations

Jun 5, 2021·Journal of Cutaneous Pathology·Neslihan AkdoganSerdar Nasir
Jul 27, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·R M Trüeb
Jan 12, 2020·Journal of the American Academy of Dermatology·Jacob GriggsAntonella Tosti
Aug 2, 2019·Skin Appendage Disorders·Laura SilvaJuliana Dumet Fernandes

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Methods Mentioned

BETA
biopsies
biopsy

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