Feb 25, 1976

Graft-versus-host reaction: a pathogenetic principle for the development of drug allergy, autoimmunity, and malignant lymphoma in non-chimeric individuals. Hypothesis

Zeitschrift Für Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology
E Gleichmann, H Gleichmann


It is proposed that the same diseases as those induced by the graft-versus-host reaction (GVHR) will arise in nonchimeric individuals, if structures of the major histocompatibility complex (MHC) on lymphocytes are altered, either by viral infection or by chemicals, in such a way that autologous T lymphocytes react against them as the react in the GVHR to semiallogeneic (F1) lymphocytes differing at the MHC. Diseases in which a GVHR-like pathogenesis is suspected will be discussed.

  • References72
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Mentioned in this Paper

Pathogenic Aspects
Infectious Mononucleosis
Virus Diseases
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Binding Sites, Antibody
Graft-vs-Host Disease
Chimera Organism

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