PMID: 972Dec 1, 1975

Graft versus host reaction. An ultrastructural study

Archives of Dermatology
G De DobbeleerG Achten


Graft versus host reaction (GvH) following leukocytic transfusions occurred in a 34-year-old man with a generalized lymphosarcoma. Histologic and ultrastructural studies were performed, with special reference to dyskeratotic cells scattered in the epidermis. These cells are usually considered to be a constant and important feature of GvH reaction. Dense aggregation of tonofilaments, including cytoplasmic organelles and loss of desmosomes, were seen in dyskeratotic cells. Several intracellular desmosomes with tonofilaments bound to their attachment plaque were observed. Some of these cells were able to reach the horny layer; some others were phagocytosed by neighboring keratinocytes. These cells could be the result of a toxic damage to the epidermis, provoked by the immunologic phenomenon implicated in GvH reaction. Later in the clinical course, bullae formations occurred, showing some features of toxic epidermal necrolysis (TEN), as well as features of GvH reaction.


Aug 2, 1990·The New England Journal of Medicine·K C Anderson, H J Weinstein
Mar 1, 1977·The British Journal of Dermatology·G De Dobbeleer, G Achten
Sep 1, 1976·International Journal of Dermatology·M J Fellner
Nov 1, 1992·International Journal of Dermatology·J M Parsons
Aug 1, 1978·The Australasian Journal of Dermatology·D Weedon, I Robertson
Dec 1, 1981·Ophthalmology·R J Campbell, W M Bourne
Apr 1, 1992·Transfusion Medicine Reviews·J V Linden, P T Pisciotto
Jul 10, 2001·The Journal of Investigative Dermatology·M C PickeringH T Cook
Feb 1, 1992·Journal of the American Academy of Dermatology·J L HeldR J Margolis
Apr 1, 1980·The British Journal of Dermatology·J M MascaróJ Mallolas
Feb 1, 1986·The British Journal of Dermatology·J GoensG Achten
Dec 1, 1980·Journal of Cutaneous Pathology·C RozmanT Castel
Jun 1, 1982·Journal of Cutaneous Pathology·K Danno, T Horio
May 1, 1981·International Journal of Dermatology·J H Saurat
Jun 1, 1982·The American Journal of Medicine·V von FliednerU Kim

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Graft Vs Host Reaction
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