PMID: 6403650Mar 1, 1983Paper

Graft-vs.-host-associated immune suppression is activated by recognition of allogeneic murine I-A antigens

The Journal of Experimental Medicine
G M Shearer, R B Levy

Abstract

Several combinations of F1 hybrid mice were injected intravenously with parental spleen cells to determine the minimal H-2 differences between F1 and parent that are necessary to induce graft-vs.-host-associated immune suppression (GVH-associated suppression). 7-14 d after injection, the spleens of the F1 mice were tested for cytotoxic T lymphocyte potential by in vitro sensitization against trinitrophenyl-self and H-2 alloantigens. The results indicate that parental T lymphocytes must recognize I-A allogeneic determinants of the F1 recipient in order to induce suppression. Recognition of K or D alone or D with I region products other than I-A did not induce suppression. The recognition of I region without K and/or D and even the I-A difference between C57BL/6 and the B6.Cbm12 mutation resulted in immune suppression that was as potent as that resulting from the recognition of K, D, and I together. The possible significance of this function for I-A antigens is discussed with respect to three clinical examples of immune suppression for which this phenomenon may be relevant.

References

Dec 1, 1979·The Journal of Experimental Medicine·I F McKenzieH I Kohn
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·C G FathmanC S David
Nov 1, 1982·The Journal of Experimental Medicine·C K HurleyJ D Capra
Aug 1, 1980·The American Journal of Medicine·H M ShulmanE D Thomas
Sep 9, 1982·Nature·J E Groopman, M S Gottlieb

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Citations

Jan 1, 1988·Immunologic Research·M Fukuzawa, G M Shearer
Jun 14, 1984·The New England Journal of Medicine
Jul 19, 1984·The New England Journal of Medicine
Jan 1, 1983·AIDS Research·J A Sonnabend, S Saadoun
May 1, 1986·Immunological Investigations·D E Mosier
Jan 1, 1988·Immunopharmacology and Immunotoxicology·S R SmithS Umland
Aug 1, 1986·Scandinavian Journal of Immunology·P Langlade Demoyen, E L Larsson
Dec 1, 1985·Immunological Reviews·M MoserG M Shearer
Aug 1, 1983·Immunology Today·R S Geha, F S Rosen
Nov 15, 1989·International Journal of Cancer. Journal International Du Cancer·R Evans, T M Duffy
May 1, 1989·International Reviews of Immunology·H G Rammensee
Aug 1, 1992·European Journal of Immunology·S C MulukG M Shearer
Jan 1, 1988·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·C F KuperF M Hofhuis

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