Grafting antibiofilm polymer hydrogel film onto catheter by SARA SI-ATRP

Journal of Biomaterials Science. Polymer Edition
Chao ZhouBo Liu

Abstract

Catheters are widely used and play an important role in medicine. However, catheter-associated infection is prevalent even under stringent sterile conditions. Biofilms are formed when bacteria populate the surfaces of catheters. This makes the biofilm resistant to antibiotics. Hence, it is imperative for there to be an inherently antifouling and anti-bacterial catheter to mitigate the formation of biofilm. This paper aims to outline the synthesis of non-leachable anti-biofilm and anti-bacterial cationic film coatings through direct polymerization using supplemental activator and reducing agent surface initiated atom transfer radical polymerization (SARA SI-ATRP). Three crosslinked cationic coatings comprising of Diallyl dimethyl ammonium chloride (DADMAC), or ε-poly-L-lysine HCl methacrylic acid (EPL-MA) together with a crosslinker (polyethylene glycol dimethacrylate, PEGDMA) were investigated. These non-leachable covalently linked coatings with DADMAC can achieve more than 2 log reduction (99.0%) with Methicillin-resistant Staphylococcus aureus (MRSA) and 1.25 log reduction (94.4%) with Vancomycin resistant Enterococcus (VRE) in in vitro studies.

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Citations

Jan 30, 2021·Frontiers in Microbiology·Indu SinghPradeep Kumar
Aug 28, 2020·Chemical Engineering Journal·Bo LiuBruce P Lee
Oct 4, 2020·Advances in Colloid and Interface Science·Changwen ZhaoWantai Yang
Nov 26, 2021·Letters in Applied Microbiology·P ReginattoA M Fuentefria

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Methods Mentioned

BETA
X-ray
AFM
Assay
Fluorescence
Scanning Electron
fluorescence microscopy

Software Mentioned

DADMAC

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