PMID: 29071892Oct 27, 2017Paper

Grain-Moxibustion may Protect Myocardium by Reducing Oxidative Stress in Doxorubicin-induced Cardiomyopathy Rats

Zhen ci yan jiu = Acupuncture research
Yan XiaoYi-huang Gu

Abstract

To observe the effectiveness of grain-moxibustion in resisting oxidative stress in doxorubicin (DOX)-induced cardiomyopathy rats. Sixty Sprague-Dawley (SD) rats were randomly divided into blank control group (blank group), cardiomyopathy model (model) group and grain-moxibustion (moxibustion) group, with 20 rats in each one. The cardiomyopathy model was established by intraperitoneal injection of DOX (0.5 mg/100 g), once a week for 4 weeks. Grain-moxibustion was applied to "Guanyuan" (CV 4) and "Juque" (CV 14) for 5 cones, once daily for 4 weeks except the Sundays. The rats' heart rate (HR), left ventricular systolic pressure (LVSP), left ventricular diastolic pressure (LVDP), left ventricular pressure maximum rising rate (+dp/dtmax), left ventricular pressure maximum decline rate (-dp/dtmax), left ventricular pressure change time (t-dp/dtmax) were detected to evaluate the cardiac function by using a physiological signal acquisition-analysis system. The pathological changes of the myocardium were observed by optical microscopy after H.E. staining. The activity of serum lactate dehydrogenase(LDH), creatine kinase(CK) and myocardial superoxide dismutase (SOD), and myocardial malondialdehyde (MDA) and serum cardiac troponin Ⅰ(cTnⅠ...Continue Reading

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