Gram-negative bloodstream infections

International Journal of Antimicrobial Agents
Martin E Stryjewski, Helen W Boucher

Abstract

Gram-negative bloodstream infection (BSI) is both dangerous and challenging. The incidence of Gram-negative BSI rises with age in both men and women, but there are still some gender differences in terms of aetiology and acquisition. Clinical elements such as organ dysfunction are helpful in determining prognosis. During the last few years we have observed dramatic increases in resistance among Gram-negative organisms, including those causing bloodstream infections. Gram-negative pathogens producing extended-spectrum beta-lactamases are now common, and are associated with high rates of inadequate empirical treatment and mortality. In addition, carbapenem resistance is increasing, leaving clinicians with limited therapeutic options. Better knowledge of local epidemiology can help to optimize therapies. The use of cefepime has been questioned based on a recent meta-analysis showing increased mortality in patients treated with the drug. However, an analysis performed by the US Food and Drug Administration has not confirmed these results. Unfortunately, antimicrobial development has not kept pace with resistance, particularly for Gram-negative pathogens. We need therefore to better utilize current antibiotics and undertake rigorous ...Continue Reading

References

Feb 23, 2008·The Lancet Infectious Diseases·Johann D D Pitout, Kevin B Laupland
May 1, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lisa L Maragakis, Trish M Perl
May 15, 2008·The Annals of Pharmacotherapy·Shawn D Anderson, John G Gums
Oct 25, 2008·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Alicia I HidronUNKNOWN Participating National Healthcare Safety Network Facilities
Nov 28, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Helen W BoucherJohn Bartlett
Jan 13, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Malgorzata MikulskaClaudio Viscoli
Jun 17, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David L Paterson, Daryl D Depestel

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Citations

May 7, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ritu BanerjeeRobin Patel
Jun 28, 2020·The Journal of Antimicrobial Chemotherapy·María Ruiz-RuigómezJosé María Aguado
Jan 21, 2021·International Journal of Molecular Sciences·Paweł KowalczykIda Franiak-Pietryga

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