Abstract
Our aim was to describe the clinical features and prognostic factors of Gram-negative rod bacteremia (GNRB) after cardiovascular surgery (CVS). This retrospective observational study included adults with GNRB onset within 100 days after CVS at a single institution from April 2004 to May 2013. Clinical data regarding episodes of GNRB were collected from patients' medical charts. Those having polymicrobial bacteremia with a bacterium other than a GNR were excluded. Among 2017 CVS patients, GNRB occurred in 78. Klebsiella, Pseudomonas aeruginosa, Enterobacter, and Escherichia coli were the most commonly isolated organisms. Graft replacement was the most common surgical procedure in patients with GNRB after CVS (44.9%). Prophylaxis antibiotics were ampicillin/sulbactam (76.9%), and vancomycin (12.8%). The crude 90-day mortality rate was 21.8%, and the mean Acute Physiology and Chronic Health Evaluation II score was 15.6 (range, 3-39). In 34.6% of patients, the same GNR species were isolated from other samples within 30 days of GNRB occurrence. Multivariate analysis indicated that P. aeruginosa bacteremia [odds ratio (OR), 175; confidence interval (CI), 2.40-1270; p = 0.0182], Acute Physiology and Chronic Health Evaluation II scores...Continue Reading
References
Feb 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L LeiboviciM Drucker
Oct 1, 1985·Critical Care Medicine·W A KnausJ E Zimmerman
Jan 1, 1971·Archives of Internal Medicine·R E BryantM G Koenig
May 1, 1996·World Journal of Surgery·G M Swank, E A Deitch
Jul 1, 1998·Infection·A GikasN Tsaparas
Nov 30, 2002·International Journal of Antimicrobial Agents·George KoratzanisHelen Giamarellou
Mar 26, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Farrin A ManianDiane Senkel
Jun 25, 2003·Circulation·Vance G FowlerEugene Z Oddone
Aug 27, 2005·The Annals of Thoracic Surgery·Franz F ImmerThierry P Carrel
Feb 8, 2006·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Wendy SliglPeter G Brindley
Jun 29, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dale W Bratzler, David R Hunt
Aug 29, 2006·The Journal of Thoracic and Cardiovascular Surgery·Matthew E FalagasSotirios N Prapas
Sep 13, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A van Eck van der SluijsEdgar J G Peters
Nov 16, 2011·Journal of Cardiothoracic Surgery·Ioanna LolaGeorge S Papadopoulos
Jan 19, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Dale W BratzlerUNKNOWN Society for Healthcare Epidemiology of America
Aug 31, 2013·Médecine et maladies infectieuses·D LepelletierP Despins
Feb 14, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·H CharbonneauE Guerot