Gram-negative synthase-dependent exopolysaccharide biosynthetic machines

Current Opinion in Structural Biology
Kristin E Low, P Lynne Howell

Abstract

Bacteria predominantly exist as matrix embedded communities of cells called biofilms. The biofilm matrix is made up of a variety of self-produced extracellular components including DNA, proteins, and exopolysaccharides. Bacterial exopolysaccharides have been implicated in surface adhesion, resistance to antibiotics, and protection from host immune systems. Herein we review the structure and function of the proteins involved in the production of the Gram-negative synthase-dependent exopolysaccharides: alginate, poly-β(1,6)-N-acetyl-d-glucosamine (PNAG), cellulose, and the Pel polysaccharide. We highlight the similarities and differences that exist at the molecular level in these synthase systems.

Citations

Jun 18, 2019·Annual Review of Microbiology·Edward GeisingerRalph R Isberg
Jan 29, 2020·Journal of Bacteriology·Gregory B WhitfieldP Lynne Howell
May 10, 2020·Biomolecules·Maria Soledad RamirezMarcelo E Tolmasky
Jul 19, 2020·Annual Review of Microbiology·Chris WhitfieldCaitlin Sande
Apr 3, 2020·PLoS Computational Biology·Cedoljub Bundalovic-TormaJohn Parkinson
Apr 20, 2019·Environmental Science and Pollution Research International·Shalini Singh, Vipin Kumar
Mar 2, 2021·Microbiology Insights·Gregory B Whitfield, P Lynne Howell
Mar 14, 2021·Nature Structural & Molecular Biology·Justin F AchesonJochen Zimmer
Oct 20, 2020·Current Opinion in Chemical Biology·Sergi Pascual, Antoni Planas
Aug 18, 2021·MBio·Alex S GrossmanHeidi Goodrich-Blair
Oct 12, 2021·FEMS Microbiology Reviews·Wiem AbidiPetya Violinova Krasteva

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