Gram-positive bacterial sepsis in rat and tissue lipolytic activity on commercial parenteral fat emulsions

Infection
Z MeraihiA C Bach

Abstract

To study the influence of a gram-positive sepsis on the metabolism of circulating lipids, fasted rats were injected with saline (control group) or with a suspension of heat-killed or live Staphylococcus aureus. 18 h later, body temperature was increased, while albuminemia and ketonemia were decreased in the group injected with heat-killed bacteria, as opposed to the control group. Passing from these groups to the group injected with live bacteria, more differences appeared: increase of triglyceridemia and free cholesterolemia; decrease of esterified cholesterol levels and especially of the in vitro activity of diaphragm, heart and adipose tissue lipoprotein lipase and of hepatic lipase. The decrease of lipolytic activities occurred whether they were measured on a fat emulsion containing long-chain or medium- and long-chain triglycerides. The fact that for the latter the activity was always higher than for the former suggests that the host infected with gram-positive bacteria would clear exogenous fat more easily in the case of medium-chain triglycerides.

References

Jun 1, 1976·Metabolism: Clinical and Experimental·R L KaufmannW R Beisel
Dec 1, 1979·The Journal of Clinical Investigation·R W WannemacherH A Neufeld
Nov 1, 1988·JPEN. Journal of Parenteral and Enteral Nutrition·A C BachZ Meraihi
Nov 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·R H FiserW R Beisel
May 1, 1968·Journal of Bacteriology·D Farshtchi, V J Lewis
Nov 13, 1969·The New England Journal of Medicine·J I GallinW M O'Leary
Jan 1, 1984·JPEN. Journal of Parenteral and Enteral Nutrition·W J Chen
May 1, 1984·JPEN. Journal of Parenteral and Enteral Nutrition·W ParkH Schröder
Nov 1, 1982·Critical Care Medicine·M Lindholm, S Rössner
Nov 1, 1982·JPEN. Journal of Parenteral and Enteral Nutrition·H A NeufeldD J Crawford
Aug 1, 1982·Annals of Surgery·J NordenströmJ M Kinney
May 1, 1980·JPEN. Journal of Parenteral and Enteral Nutrition·W R Beisel, R W Wannemacher
Jan 1, 1962·The Biochemical Journal·D H WILLIAMSONH A KREBS
May 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·J I KESSLERH D JANOWITZ

❮ Previous
Next ❯

Citations

Feb 1, 1996·Journal of the American Dietetic Association·D T MitchellM A Novascone
May 17, 2008·Avian Pathology : Journal of the W.V.P.A·V R ParreiraT Yano
Feb 9, 2012·Avian Diseases·Subhashinie Kariyawasam, Lisa K Nolan
Mar 9, 2002·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M-T LinW-J Chen
Jun 27, 2000·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·S YehW Chen
Mar 1, 1994·JPEN. Journal of Parenteral and Enteral Nutrition·A De GaetanoA V Greco
Oct 9, 2009·Neuropsychology Review·Anna Rieckmann, Lars Bäckman
Oct 18, 2008·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Idalina BeirãoGraça Porto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.