Gramicidin A channels switch between stretch activation and stretch inactivation depending on bilayer thickness

Proceedings of the National Academy of Sciences of the United States of America
Boris Martinac, Owen P Hamill

Abstract

The patch clamp-liposome technique was used to examine the stretch sensitivity of a model membrane ion channel, gramicidin A, in membrane patches of different bilayer thickness. We found that small changes in phospholipid acyl chain length (i.e., PC-20 to PC-18) can switch gramicidin A from a stretch-activated to a stretch-inactivated channel. The demonstration that subnanometer changes in bilayer thickness can reverse the response polarity of a model channel has implications for other signaling proteins that may experience local changes in bilayer thickness as a consequence of dynamic targeting to lipid microdomains, electrocompression, or chemical modification of the bilayer.

References

Jan 4, 1977·Biochimica Et Biophysica Acta·E Neher, H Eibl
Jan 1, 1978·Hospital Topics·A M Schutta, D S Daly
Dec 11, 1992·Biochimica Et Biophysica Acta·J A Killian
Jul 3, 1990·Biochemistry·P I WatnickP Dea
Aug 1, 1991·Quarterly Reviews of Biophysics·M BloomO G Mouritsen
Aug 9, 1972·Biochimica Et Biophysica Acta·V B Myers, D A Haydon
Aug 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·D W UrryD F Mayers
Oct 26, 1983·Biochimica Et Biophysica Acta·J R ElliottD A Haydon
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
May 15, 1983·Journal of Molecular Biology·B A Lewis, D M Engelman
Jan 1, 1994·Biophysical Journal·L R Opsahl, W W Webb
Oct 1, 1994·The Journal of General Physiology·J A Lundbaek, O S Andersen
Jan 1, 1996·Annual Review of Biophysics and Biomolecular Structure·R E Koeppe, O S Anderson
Jan 1, 1995·Cold Spring Harbor Symposia on Quantitative Biology·J Dai, M P Sheetz
Aug 1, 1997·Current Opinion in Cell Biology·T Harder, K Simons
Feb 4, 1998·Biophysical Journal·M GoulianA Libchaber
Mar 7, 1998·The Journal of General Physiology·N E Schoppa, F J Sigworth
Apr 17, 1998·Biophysical Journal·C NielsenO S Andersen
Apr 29, 1998·Reviews of Physiology, Biochemistry and Pharmacology·F Sachs, C E Morris
Jan 19, 1999·Annual Review of Cell and Developmental Biology·D A Brown, E London
Mar 14, 2000·The Journal of Biological Chemistry·J R MartensM M Tamkun
Apr 15, 2000·The Journal of Biological Chemistry·T P LockwichI S Ambudkar
Nov 9, 2000·Proceedings of the National Academy of Sciences of the United States of America·M Bravo-ZehnderA González
Feb 28, 2001·The Journal of Membrane Biology·C E Morris, U Homann
Apr 28, 2001·Biophysical Journal·J GullingsrudK Schulten
Jun 20, 2001·Nature Reviews. Molecular Cell Biology·K Simons, D Toomre
Aug 2, 2001·The Journal of General Physiology·E PerozoB Martinac
Feb 6, 2002·Chembiochem : a European Journal of Chemical Biology·H D ArndtU Koert

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Citations

Nov 8, 2006·European Biophysics Journal : EBJ·Evgeny Petrov, Boris Martinac
Jun 14, 2005·Pflügers Archiv : European journal of physiology·Wolfgang Liedtke
Oct 6, 2006·Pflügers Archiv : European journal of physiology·O P Hamill
Dec 4, 2003·Current Opinion in Chemical Biology·G Andrew Woolley, Tyler Lougheed
May 7, 2003·Progress in Biophysics and Molecular Biology·Boris Martinac, Anna Kloda
May 16, 2012·Proceedings of the National Academy of Sciences of the United States of America·Takeshi NomuraBoris Martinac
Mar 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Andriy Anishkin, Ching Kung
Jun 6, 2009·The Journal of Biological Chemistry·Yen-Hua HuangDavid J Craik
Sep 30, 2010·The Journal of General Physiology·Ben CorryBoris Martinac
May 4, 2011·Cold Spring Harbor Perspectives in Biology·Francesc-Xabier ContrerasBritta Brügger
Jun 23, 2006·Clinical and Experimental Pharmacology & Physiology·Jeffry B Lansman, Alfredo Franco-Obregón
Feb 24, 2004·Molecular Pharmacology·James D BradyJeffrey R Martens
Feb 12, 2004·Science's STKE : Signal Transduction Knowledge Environment·Sergei Sukharev, David P Corey
May 13, 2006·Annual Review of Biophysics and Biomolecular Structure·Thomas J McIntosh, Sidney A Simon
Apr 17, 2009·American Journal of Physiology. Cell Physiology·Yan-Liang ZhangMirianas Chachisvilis
Oct 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Wolfgang Liedtke, Jeffrey M Friedman
Oct 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Mirianas ChachisvilisJohn A Frangos
Oct 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Wolfgang LiedtkeJeffrey M Friedman
May 23, 2014·Proceedings of the National Academy of Sciences of the United States of America·Andriy AnishkinChing Kung
Feb 13, 2008·Journal of Cellular and Molecular Medicine·Pablo V EscribáGwendolyn Barceló-Coblijn
Aug 25, 2004·Biophysical Journal·Boris G DzikovskiJack H Freed
Aug 10, 2004·Biophysical Journal·Satinder S RawatAmitabha Chattopadhyay
May 17, 2012·Biochimica Et Biophysica Acta·A Srinivas ReddyMirianas Chachisvilis
Feb 5, 2013·Biochimica Et Biophysica Acta·Ryan D Booker, Amadeu K Sum
Jul 5, 2011·Biochimica Et Biophysica Acta·Dora Toledo WarshaviakMirianas Chachisvilis
Apr 30, 2015·Biochimica Et Biophysica Acta·A R BattleB Martinac
Dec 11, 2014·Annual Review of Plant Biology·Eric S HamiltonElizabeth S Haswell
Jan 10, 2006·Developmental Cell·A Wayne OrrMartin A Schwartz
Jul 28, 2013·Biochimica Et Biophysica Acta·Boris Martinac
Mar 1, 2011·Biophysical Journal·Stephan L GrageBoris Martinac
Sep 26, 2003·Biophysical Journal·Mounir TarekChristophe Chipot
Jun 11, 2004·Biophysical Journal·Chunbo YuanSteven N Treistman
Jun 19, 2007·Biochimica Et Biophysica Acta·Devaki A Kelkar, Amitabha Chattopadhyay
Nov 16, 2004·Biophysical Journal·Marta de FrutosEric Raspaud
Oct 26, 2016·Protein Science : a Publication of the Protein Society·Xuejun C ZhangJie Li
Nov 16, 2004·Biophysical Journal·Paul Wiggins, Rob Phillips
Sep 7, 2005·Respiratory Physiology & Neurobiology·Jerry Yu

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