PMID: 8593271Jan 31, 1996Paper

Gramicidin channel-induced lipid membrane deformation energy: influence of chain length and boundary conditions

Biochimica Et Biophysica Acta
A Ring

Abstract

The influence of boundary conditions on the deformation energy of a lipid membrane containing a gramicidin A channel was evaluated numerically. A liquid crystal model was used to calculate the relative contributions of compression, splay and surface tension. It is proposed that the nearest neighbor lipid molecules are displaced from the channel end in a direction perpendicular to the bilayer and it is concluded that surface tension is the major component of the deformation free energy for monoolein (gmo)/n-alkane membranes. This unexpected result supports the validity of the liquid crystal models of membrane deformation since gramicidin lifetime has been shown to correlate with surface tension for gmo membranes. The theory accurately predicts the experimentally measured relative lifetimes without the use of adjustable parameters. For conditions where splay may be neglected surface tension is always the major component of the deformation energy, irrespective of the magnitude of the compression coefficient. The deformation may extend for hundreds of angstroms from the peptide. The results obtained here are expected to be important for the characterization of protein-membrane interactions in general.

References

Jan 4, 1977·Biochimica Et Biophysica Acta·E Neher, H Eibl
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J C Owicki, H M McConnell
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Citations

Feb 4, 1998·Biophysical Journal·M GoulianA Libchaber
Dec 6, 2005·Biophysical Journal·Grace Brannigan, Frank L H Brown
May 8, 1997·Biochemical and Biophysical Research Communications·A Ring, A C Mörk
Dec 26, 2003·Biophysical Journal·Gennady V Miloshevsky, Peter C Jordan
Oct 29, 2000·Biophysical Journal·C Nielsen, O S Andersen
Jul 21, 2001·Biophysical Journal·J SandblomB Jilderos
Apr 17, 1998·Biophysical Journal·C NielsenO S Andersen
Feb 28, 2002·Biophysical Journal·Kathryn M Armstrong, Samuel Cukierman
Mar 30, 2017·Biophysical Journal·Alexander J SodtRichard W Pastor
May 7, 2005·Physical Chemistry Chemical Physics : PCCP·R A KikJ M Kleijn
Apr 12, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Kong-Ju-Bock Lee
Apr 7, 2010·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Richard A KikJ Mieke Kleijn
May 26, 2017·Biophysical Journal·David ArgudoMichael Grabe
Nov 7, 1998·Biochimica Et Biophysica Acta·T GilM J Zuckermann
Sep 6, 2017·Journal of Chemical Theory and Computation·Andrew H BeavenWonpil Im

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