Graminex Pollen: Phenolic Pattern, Colorimetric Analysis and Protective Effects in Immortalized Prostate Cells (PC3) and Rat Prostate Challenged with LPS

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
M LocatelliG Orlando

Abstract

Prostatitis, a general term describing prostate inflammation, is a common disease that could be sustained by bacterial or non-bacterial infectious agents. The efficacy of herbal extracts with antioxidant and anti-inflammatory effects for blunting the burden of inflammation and oxidative stress, with possible improvements in clinical symptoms, is under investigation. Pollen extracts have been previously reported as promising agents in managing clinical symptoms related to prostatitis. The aim of the present work was to evaluate the protective effects of Graminex pollen (GraminexTM, Deshler, OH, USA), a commercially available product based on standardized pollen extracts, in rat prostate specimens, ex vivo. In this context, we studied the putative mechanism of action of pollen on multiple inflammatory pathways, including the reduction of prostaglandin E₂ (PGE₂), nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB), and malondialdehyde (MDA), whose activities were significantly increased by inflammatory stimuli. We characterized by means of chromatographic and colorimetric studies the composition of Graminex pollen to better correlate the activity of pollen on immortalized prostate cells (PC3), and in rat prostate...Continue Reading

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Citations

Dec 6, 2018·International Journal of Environmental Health Research·Gokhan ZenginMohamad Fawzi Mahomoodally
Mar 31, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andrei MocanMarcello Locatelli
Dec 21, 2018·International Journal of Molecular Sciences·Chen ShaoDexin Kong
Sep 15, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shao-Nan WangJin-Li Shi
Sep 5, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chung Pui PingMohd Roslan Sulaiman
Mar 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhenhuang ShenPeiying Shi
Nov 24, 2019·Antioxidants·Rodica MărgăoanDan C Vodnar
Mar 24, 2021·Journal of Enzyme Inhibition and Medicinal Chemistry·Ercüment AksakalClaudiu T Supuran
May 11, 2021·Frontiers in Pharmacology·Carlos Martinez-ArmentaAlberto López-Reyes
Jun 14, 2021·Journal of Ethnopharmacology·Siti Zaidathul Iman ZolkifflyMuhammad Zulfadli Mehat

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Methods Mentioned

BETA
column chromatography
MDA

Software Mentioned

GraphPad Prism
Empower
GraphPad
CIELAB

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